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Ppp1r15a protein phosphatase 1, regulatory subunit 15A [ Mus musculus (house mouse) ]

Gene ID: 17872, updated on 8-Jan-2023

Summary

Official Symbol
Ppp1r15aprovided by MGI
Official Full Name
protein phosphatase 1, regulatory subunit 15Aprovided by MGI
Primary source
MGI:MGI:1927072
See related
Ensembl:ENSMUSG00000040435 AllianceGenome:MGI:1927072
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gadd34; Myd116; 9630030H21
Summary
Enables protein phosphatase binding activity and protein phosphatase regulator activity. Involved in several processes, including peptidyl-serine dephosphorylation; regulation of gene expression; and regulation of protein modification process. Acts upstream of or within endoplasmic reticulum unfolded protein response. Predicted to be located in several cellular components, including Golgi apparatus; cytosol; and mitochondrion. Predicted to be part of protein phosphatase type 1 complex. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including central nervous system; genitourinary system; gut; hemolymphoid system gland; and liver. Used to study thalassemia. Orthologous to human PPP1R15A (protein phosphatase 1 regulatory subunit 15A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14 (RPKM 79.4), liver E14.5 (RPKM 76.2) and 26 other tissues See more
Orthologs
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Genomic context

See Ppp1r15a in Genome Data Viewer
Location:
7; 7 B3
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (45172341..45175692, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45522917..45526268, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene dihydrodiol dehydrogenase (dimeric) Neighboring gene tubby-like protein 2 Neighboring gene nucleobindin 1 Neighboring gene pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 Neighboring gene predicted gene, 53387 Neighboring gene hydroxysteroid (17-beta) dehydrogenase 14

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein phosphatase 1 binding ISO
Inferred from Sequence Orthology
more info
 
enables protein phosphatase binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein phosphatase regulator activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within endoplasmic reticulum unfolded protein response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell death ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of phosphoprotein phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein processing ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of response to endoplasmic reticulum stress IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidyl-serine dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of peptidyl-serine dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of peptidyl-serine dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of phosphoprotein phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of phosphoprotein phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase I IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein localization to endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of translation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of translational initiation by eIF2 alpha dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in response to endoplasmic reticulum stress IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to endoplasmic reticulum stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
part_of protein phosphatase type 1 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of protein phosphatase type 1 complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein phosphatase 1 regulatory subunit 15A
Names
growth arrest and DNA damage-inducible protein GADD34
growth arrest and DNA-damage-inducible 34
myeloid differentiation primary response gene 116
myeloid differentiation primary response protein MyD116
protein phosphatase 1, regulatory (inhibitor) subunit 15A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008654.2NP_032680.1  protein phosphatase 1 regulatory subunit 15A

    See identical proteins and their annotated locations for NP_032680.1

    Status: VALIDATED

    Source sequence(s)
    AC151602, AK079339, AW493042, BC138486
    Consensus CDS
    CCDS21249.1
    UniProtKB/Swiss-Prot
    P17564, Q8C579
    UniProtKB/TrEMBL
    B2RRL7
    Related
    ENSMUSP00000049488.9, ENSMUST00000042105.11
    Conserved Domains (1) summary
    pfam10488
    Location:545612
    PP1c_bdg; Phosphatase-1 catalytic subunit binding region

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    45172341..45175692 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)