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TRDMT1 tRNA aspartic acid methyltransferase 1 [ Homo sapiens (human) ]

Gene ID: 1787, updated on 13-Mar-2020

Summary

Official Symbol
TRDMT1provided by HGNC
Official Full Name
tRNA aspartic acid methyltransferase 1provided by HGNC
Primary source
HGNC:HGNC:2977
See related
Ensembl:ENSG00000107614 MIM:602478
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DMNT2; DNMT2; PUMET; RNMT1; MHSAIIP
Summary
This gene encodes a protein responsible for the methylation of aspartic acid transfer RNA, specifically at the cytosine-38 residue in the anticodon loop. This enzyme also possesses residual DNA-(cytosine-C5) methyltransferase activity. While similar in sequence and structure to DNA cytosine methyltransferases, this gene is distinct and highly conserved in its function among taxa. [provided by RefSeq, Jun 2010]
Expression
Ubiquitous expression in thyroid (RPKM 1.0), endometrium (RPKM 0.6) and 25 other tissues See more
Orthologs

Genomic context

See TRDMT1 in Genome Data Viewer
Location:
10p13
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (17137336..17202071, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (17179828..17244093, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376435 Neighboring gene cubilin Neighboring gene GATA motif-containing MPRA enhancer 283 Neighboring gene VIM antisense RNA 1 Neighboring gene vimentin Neighboring gene ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 Neighboring gene ST8SIA6 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease.
NHGRI GWA Catalog
Genome wide association and linkage analyses identified three loci-4q25, 17q23.2, and 10q11.21-associated with variation in leukocyte telomere length: the Long Life Family Study.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding IEA
Inferred from Electronic Annotation
more info
 
tRNA (cytosine-5-)-methyltransferase activity EXP
Inferred from Experiment
more info
PubMed 
tRNA (cytosine-5-)-methyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
tRNA methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
response to amphetamine IEA
Inferred from Electronic Annotation
more info
 
tRNA methylation IDA
Inferred from Direct Assay
more info
PubMed 
tRNA modification TAS
Traceable Author Statement
more info
 
tRNA stabilization ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
tRNA (cytosine(38)-C(5))-methyltransferase
Names
DNA (cytosine-5)-methyltransferase-like protein 2
DNA MTase homolog HsaIIP
DNA cytosine-5 methyltransferase 2
DNA methyltransferase-2
tRNA (cytosine-5-)-methyltransferase
NP_001307935.1
NP_001307936.1
NP_001338148.1
NP_001338149.1
NP_001338150.1
NP_001338151.1
NP_001338152.1
NP_004403.1
XP_005252431.1
XP_005252432.1
XP_005252435.1
XP_011517645.1
XP_011517646.1
XP_011517647.1
XP_016871290.1
XP_016871291.1
XP_016871292.1
XP_016871293.1
XP_016871295.1
XP_016871298.1
XP_016871299.1
XP_016871301.1
XP_024303623.1
XP_024303624.1
XP_024303625.1
XP_024303626.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321006.2NP_001307935.1  tRNA (cytosine(38)-C(5))-methyltransferase isoform f

    Status: REVIEWED

    Source sequence(s)
    AC067747, AJ223333, AK299027, AW136056
    UniProtKB/Swiss-Prot
    O14717
    UniProtKB/TrEMBL
    B4DQZ2
    Conserved Domains (1) summary
    cl17173
    Location:25310
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  2. NM_001321007.2NP_001307936.1  tRNA (cytosine(38)-C(5))-methyltransferase isoform g

    Status: REVIEWED

    Source sequence(s)
    AC067747, AJ223333, AK299027, AL133415, AW136056, BX537961
    UniProtKB/Swiss-Prot
    O14717
    UniProtKB/TrEMBL
    B4DQZ2, Q7Z3E4
    Conserved Domains (1) summary
    cl17173
    Location:1320
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  3. NM_001351219.2NP_001338148.1  tRNA (cytosine(38)-C(5))-methyltransferase isoform h

    Status: REVIEWED

    Source sequence(s)
    AC067747, AF329941, AJ223333, AW136056, HY167774
    Conserved Domains (1) summary
    cd00315
    Location:4384
    Cyt_C5_DNA_methylase; Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group ...
  4. NM_001351220.1NP_001338149.1  tRNA (cytosine(38)-C(5))-methyltransferase isoform i

    Status: REVIEWED

    Source sequence(s)
    AA399591, AC067747, AJ223333, AK294100, AL133415, BF435781, BX117729, CN304214, DC411638
    Conserved Domains (1) summary
    cl17173
    Location:4359
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  5. NM_001351221.2NP_001338150.1  tRNA (cytosine(38)-C(5))-methyltransferase isoform j

    Status: REVIEWED

    Source sequence(s)
    AC067747, AF329941, AJ223333, AW136056
    Conserved Domains (1) summary
    cl17173
    Location:4338
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  6. NM_001351222.1NP_001338151.1  tRNA (cytosine(38)-C(5))-methyltransferase isoform k

    Status: REVIEWED

    Source sequence(s)
    AC067747, AJ223333, AK294100, AL133415, BF435781, BX494949, CN304214, DC411638, DC416110
    Conserved Domains (1) summary
    cl17173
    Location:1281
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  7. NM_001351223.1NP_001338152.1  tRNA (cytosine(38)-C(5))-methyltransferase isoform k

    Status: REVIEWED

    Source sequence(s)
    AC067747, AJ223333, AK294100, AL133415, BF435781, CN304214, DC411638, DC416110
    Conserved Domains (1) summary
    cl17173
    Location:1281
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  8. NM_004412.7NP_004403.1  tRNA (cytosine(38)-C(5))-methyltransferase isoform a

    See identical proteins and their annotated locations for NP_004403.1

    Status: REVIEWED

    Source sequence(s)
    AC067747, AJ223333, AW136056
    Consensus CDS
    CCDS7114.1
    UniProtKB/Swiss-Prot
    O14717
    UniProtKB/TrEMBL
    Q6ICS7
    Related
    ENSP00000367030.3, ENST00000377799.8
    Conserved Domains (1) summary
    cd00315
    Location:4391
    Cyt_C5_DNA_methylase; Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    17137336..17202071 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005252374.5XP_005252431.1  tRNA (cytosine(38)-C(5))-methyltransferase isoform X4

    Conserved Domains (1) summary
    cl17173
    Location:4359
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  2. XM_017015809.1XP_016871298.1  tRNA (cytosine(38)-C(5))-methyltransferase isoform X13

  3. XM_011519344.2XP_011517646.1  tRNA (cytosine(38)-C(5))-methyltransferase isoform X6

    See identical proteins and their annotated locations for XP_011517646.1

    Conserved Domains (1) summary
    cl17173
    Location:25332
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  4. XM_005252375.4XP_005252432.1  tRNA (cytosine(38)-C(5))-methyltransferase isoform X5

    See identical proteins and their annotated locations for XP_005252432.1

    UniProtKB/Swiss-Prot
    O14717
    Conserved Domains (1) summary
    cl17173
    Location:4345
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  5. XM_024447856.1XP_024303624.1  tRNA (cytosine(38)-C(5))-methyltransferase isoform X3

    Conserved Domains (1) summary
    cl17173
    Location:4367
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  6. XM_011519343.2XP_011517645.1  tRNA (cytosine(38)-C(5))-methyltransferase isoform X2

    UniProtKB/TrEMBL
    A0A0U1U562
    Conserved Domains (1) summary
    cl17173
    Location:4369
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  7. XM_017015804.2XP_016871293.1  tRNA (cytosine(38)-C(5))-methyltransferase isoform X8

    Conserved Domains (1) summary
    cl17173
    Location:1320
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  8. XM_017015806.1XP_016871295.1  tRNA (cytosine(38)-C(5))-methyltransferase isoform X9

  9. XM_024447857.1XP_024303625.1  tRNA (cytosine(38)-C(5))-methyltransferase isoform X11

    Conserved Domains (1) summary
    cl17173
    Location:1298
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  10. XM_024447858.1XP_024303626.1  tRNA (cytosine(38)-C(5))-methyltransferase isoform X12

    Conserved Domains (1) summary
    cl17173
    Location:1296
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  11. XM_017015803.2XP_016871292.1  tRNA (cytosine(38)-C(5))-methyltransferase isoform X8

    Conserved Domains (1) summary
    cl17173
    Location:1320
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  12. XM_017015802.2XP_016871291.1  tRNA (cytosine(38)-C(5))-methyltransferase isoform X8

    Conserved Domains (1) summary
    cl17173
    Location:1320
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  13. XM_011519345.3XP_011517647.1  tRNA (cytosine(38)-C(5))-methyltransferase isoform X6

    See identical proteins and their annotated locations for XP_011517647.1

    Conserved Domains (1) summary
    cl17173
    Location:25332
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  14. XM_017015812.1XP_016871301.1  tRNA (cytosine(38)-C(5))-methyltransferase isoform X15

  15. XM_017015801.1XP_016871290.1  tRNA (cytosine(38)-C(5))-methyltransferase isoform X7

  16. XM_024447855.1XP_024303623.1  tRNA (cytosine(38)-C(5))-methyltransferase isoform X1

    Conserved Domains (1) summary
    cl17173
    Location:4352
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  17. XM_017015810.1XP_016871299.1  tRNA (cytosine(38)-C(5))-methyltransferase isoform X14

  18. XM_005252378.3XP_005252435.1  tRNA (cytosine(38)-C(5))-methyltransferase isoform X10

    Conserved Domains (1) summary
    cl17173
    Location:1288
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_176081.2: Suppressed sequence

    Description
    NM_176081.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  2. NM_176083.2: Suppressed sequence

    Description
    NM_176083.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  3. NM_176084.1: Suppressed sequence

    Description
    NM_176084.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
  4. NM_176085.1: Suppressed sequence

    Description
    NM_176085.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
  5. NM_176086.1: Suppressed sequence

    Description
    NM_176086.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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