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hsp-16.41 Heat shock protein Hsp-16.41 [ Caenorhabditis elegans ]

Gene ID: 178660, updated on 6-Jul-2026
Official Symbol
hsp-16.41
Official Full Name
Heat shock protein Hsp-16.41
Primary source
WormBase:WBGene00002018
Locus tag
CELE_Y46H3A.2
See related
AllianceGenome:WB:WBGene00002018
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable unfolded protein binding activity. Involved in defense response to Gram-negative bacterium and response to heat. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary muscle; coelomocyte; intestine; neurons; and ventral nerve cord. Human ortholog(s) of this gene implicated in cataract 9 multiple types. Orthologous to human CRYAA (crystallin alpha A). [provided by Alliance of Genome Resources, Jul 2025]
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See hsp-16.41 in Genome Data Viewer
Location:
chromosome: V
Exon count:
2
Sequence:
Chromosome: V; NC_003283.11 (1805178..1805875)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Activin_recp domain-containing protein Neighboring gene Serpentine Receptor, class T Neighboring gene Heat shock protein hsp-16.2;SHSP domain-containing protein Neighboring gene 7TM_GPCR_Srx domain-containing protein;Serpentine Receptor, class T Neighboring gene Cysteine-rich transmembrane CYSTM domain-containing protein;Lipoprotein;RadC domain-containing protein Neighboring gene Fungal lipase-type domain-containing protein

Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Temporal and spatial expression patterns of the small heat shock (hsp16) genes in transgenic Caenorhabditis elegans. Stringham EG, et al. Mol Biol Cell, 1992 Feb. PMID 1550963, Free PMC Article
  2. Differential regulation of closely related members of the hsp16 gene family in Caenorhabditis elegans. Jones D, et al. DNA, 1989 Sep. PMID 2475316
  3. Structure, expression, and evolution of a heat shock gene locus in Caenorhabditis elegans that is flanked by repetitive elements. Jones D, et al. J Biol Chem, 1986 Sep 15. PMID 3017958
  4. Mutations in the NXF-1:NXT-1 mRNA export complex affect gene-expression driven by the hsp-16.41 promoter. Crawford MW, et al. MicroPubl Biol, 2023. PMID 37583452, Free PMC Article
  5. BuShen HuoXue decoction improves fertility through intestinal hsp-16.2-mediated heat-shock signaling pathway in Caenorhabditis elegans. Wu K, et al. Front Pharmacol, 2023. PMID 37332356, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in IRE1-mediated unfolded protein response HEP PubMed 
involved_in defense response to Gram-negative bacterium IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in endoplasmic reticulum unfolded protein response HEP PubMed 
involved_in protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to heat IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to heat IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
Heat shock protein Hsp-16.41
NP_872116.2
  • Confirmed by transcript evidence

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    1805178..1805875
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_182316.5 → NP_872116.2  Heat shock protein Hsp-16.41

    See identical proteins and their annotated locations for NP_872116.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P02514, P06581
    Conserved Domains (1) summary
    cd06526
    Location:46 → 127
    metazoan_ACD; Alpha-crystallin domain (ACD) of metazoan alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P06581.1

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