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Mybl2 myeloblastosis oncogene-like 2 [ Mus musculus (house mouse) ]

Gene ID: 17865, updated on 8-Dec-2022

Summary

Official Symbol
Mybl2provided by MGI
Official Full Name
myeloblastosis oncogene-like 2provided by MGI
Primary source
MGI:MGI:101785
See related
Ensembl:ENSMUSG00000017861 AllianceGenome:MGI:101785
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bmyb; B-Myb
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within cellular response to leukemia inhibitory factor and mitotic spindle assembly. Located in nucleus. Part of Myb complex. Is expressed in several structures, including brain; early conceptus; genitourinary system; hemolymphoid system; and skin. Used to study acute myeloid leukemia and myelodysplastic syndrome. Orthologous to human MYBL2 (MYB proto-oncogene like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14.5 (RPKM 17.0), liver E14 (RPKM 15.7) and 17 other tissues See more
Orthologs
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Genomic context

See Mybl2 in Genome Data Viewer
Location:
2 H2; 2 84.0 cM
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (162896246..162926608)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (163054327..163084688)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene serum/glucocorticoid regulated kinase 2 Neighboring gene intraflagellar transport 52 Neighboring gene microRNA 7003 Neighboring gene gametocyte specific factor 1-like Neighboring gene predicted gene 11454

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (8)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
part_of Myb complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
myb-related protein B
Names
myb-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008652.2NP_032678.1  myb-related protein B

    See identical proteins and their annotated locations for NP_032678.1

    Status: PROVISIONAL

    Source sequence(s)
    AK028497
    Consensus CDS
    CCDS17006.1
    UniProtKB/Swiss-Prot
    P48972
    Related
    ENSMUSP00000018005.4, ENSMUST00000018005.10
    Conserved Domains (4) summary
    smart00717
    Location:83131
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    pfam00249
    Location:83129
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam09316
    Location:454599
    Cmyb_C; C-myb, C-terminal
    pfam13921
    Location:3494
    Myb_DNA-bind_6; Myb-like DNA-binding domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    162896246..162926608
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498875.5XP_006498938.1  myb-related protein B isoform X2

    Conserved Domains (3) summary
    PLN03091
    Location:81219
    PLN03091; hypothetical protein; Provisional
    pfam09316
    Location:317497
    Cmyb_C; C-myb, C-terminal
    pfam13921
    Location:3494
    Myb_DNA-bind_6; Myb-like DNA-binding domain
  2. XM_006498876.5XP_006498939.1  myb-related protein B isoform X3

    See identical proteins and their annotated locations for XP_006498939.1

    Conserved Domains (2) summary
    PLN03091
    Location:257
    PLN03091; hypothetical protein; Provisional
    pfam09316
    Location:292476
    Cmyb_C; C-myb, C-terminal
  3. XM_006498873.5XP_006498936.1  myb-related protein B isoform X1

    Conserved Domains (3) summary
    PLN03091
    Location:81219
    PLN03091; hypothetical protein; Provisional
    pfam09316
    Location:454638
    Cmyb_C; C-myb, C-terminal
    pfam13921
    Location:3494
    Myb_DNA-bind_6; Myb-like DNA-binding domain
  4. XM_006498878.5XP_006498941.1  myb-related protein B isoform X4

    Conserved Domains (3) summary
    PLN03091
    Location:81219
    PLN03091; hypothetical protein; Provisional
    pfam09316
    Location:317458
    Cmyb_C; C-myb, C-terminal
    pfam13921
    Location:3494
    Myb_DNA-bind_6; Myb-like DNA-binding domain