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unc-60 Actin-depolymerizing factor 2 [ Caenorhabditis elegans ]

Gene ID: 178640, updated on 10-Oct-2019

Summary

Gene symbol
unc-60
Gene description
Actin-depolymerizing factor 2
Primary source
WormBase:WBGene00006794
Locus tag
CELE_C38C3.5
Gene type
protein coding
RNA name
Actin-depolymerizing factor 2, isoform c
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis

Genomic context

See unc-60 in Genome Data Viewer
Location:
chromosome: V
Exon count:
5
Sequence:
Chromosome: V; NC_003283.11 (1475086..1479587)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Prion-like-(Q/N-rich)-domain-bearing protein Neighboring gene hypothetical protein Neighboring gene Actin-depolymerizing factor 1 Neighboring gene Protein kinase domain-containing protein Neighboring gene hypothetical protein

Bibliography

Pathways from BioSystems

  • Cell Division: First embryonic mitosis, organism-specific biosystem (from WikiPathways)
    Cell Division: First embryonic mitosis, organism-specific biosystem"Prior to fertilization, C. elegans oocytes are arrested in meiotic prophase with nuclei containing two copies of the diploid genome packaged into recombined bivalent chromosomes. The two rounds of m...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
actin binding IEA
Inferred from Electronic Annotation
more info
 
actin filament binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
actin filament depolymerization IDA
Inferred from Direct Assay
more info
PubMed 
actin filament depolymerization IEA
Inferred from Electronic Annotation
more info
 
actin filament depolymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
actin filament severing IDA
Inferred from Direct Assay
more info
PubMed 
embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
PubMed 
locomotion IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of actin filament polymerization IDA
Inferred from Direct Assay
more info
PubMed 
skeletal muscle thin filament assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
ribonucleoprotein complex IPI
Inferred from Physical Interaction
more info
PubMed 
striated muscle thin filament IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
Actin-depolymerizing factor 2
NP_503427.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    1475086..1479587
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_071026.8NP_503427.2  Actin-depolymerizing factor 2, isoform c [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_503427.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q07749
    Conserved Domains (1) summary
    cd11286
    Location:3146
    ADF_cofilin_like; Cofilin, Destrin, and related actin depolymerizing factors
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