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Mxi1 MAX interactor 1, dimerization protein [ Mus musculus (house mouse) ]

Gene ID: 17859, updated on 23-Jun-2021

Summary

Official Symbol
Mxi1provided by MGI
Official Full Name
MAX interactor 1, dimerization proteinprovided by MGI
Primary source
MGI:MGI:97245
See related
Ensembl:ENSMUSG00000025025
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mad2; Gm10197; bHLHc11
Summary
This gene encodes a protein containing a helix-loop-helix domain characteristic of transcription factors, which allows heterodimerization and sequence-specific DNA binding. The encoded protein is related to a family of Myc/Max/Mad proteins that are involved in the regulation of several cellular processes. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate Myc function. Three alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in small intestine adult (RPKM 8.9), testis adult (RPKM 8.5) and 28 other tissues See more
Orthologs
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Genomic context

See Mxi1 in Genome Data Viewer
Location:
19 D2; 19 47.53 cM
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (53298509..53361724)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (53310128..53373293)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (53384996..53450300)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700001K23 gene Neighboring gene predicted gene, 36339 Neighboring gene predicted gene, 30541 Neighboring gene survival motor neuron domain containing 1 Neighboring gene VISTA enhancer mm1351

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008542.3NP_001008542.2  max-interacting protein 1 isoform b

    See identical proteins and their annotated locations for NP_001008542.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), also referred to as SRalpha, differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (b) is longer and has a distinct N-terminus compared to isoform a.
    Source sequence(s)
    AC133451, BC064453
    Consensus CDS
    CCDS38022.1
    UniProtKB/TrEMBL
    Q3U3X2, Q6P2L3
    Related
    ENSMUSP00000003870.8, ENSMUST00000003870.15
    Conserved Domains (1) summary
    smart00353
    Location:140192
    HLH; helix loop helix domain
  2. NM_001008543.3NP_001008543.1  max-interacting protein 1 isoform c

    See identical proteins and their annotated locations for NP_001008543.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), also referred to as WR, differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (c) is shorter and has a distinct N-terminus, compared to isoform a. This variant is supported by mRNAs and ESTs but the existence of the protein product has not been verified experimentally. Variants 3-6 encode the same protein.
    Source sequence(s)
    AC133451, L38821
    Consensus CDS
    CCDS38023.1
    UniProtKB/Swiss-Prot
    P50540
    Related
    ENSMUSP00000158401.2, ENSMUST00000235201.2
    Conserved Domains (2) summary
    TIGR02169
    Location:75155
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    cd18930
    Location:32111
    bHLHzip_MXI1; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-interacting protein 1 (MXI1) and similar proteins
  3. NM_001360345.1NP_001347274.1  max-interacting protein 1 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (c) is shorter and has a distinct N-terminus, compared to isoform a. This variant is supported by mRNAs and ESTs but the existence of the protein product has not been verified experimentally. Variants 3-6 encode the same protein.
    Source sequence(s)
    AC133451
    Consensus CDS
    CCDS38023.1
    Related
    ENSMUSP00000025998.9, ENSMUST00000025998.15
    Conserved Domains (2) summary
    TIGR02169
    Location:75155
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    cd18930
    Location:32111
    bHLHzip_MXI1; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-interacting protein 1 (MXI1) and similar proteins
  4. NM_001360346.1NP_001347275.1  max-interacting protein 1 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (c) is shorter and has a distinct N-terminus, compared to isoform a. This variant is supported by mRNAs and ESTs but the existence of the protein product has not been verified experimentally. Variants 3-6 encode the same protein.
    Source sequence(s)
    AC133451
    Consensus CDS
    CCDS38023.1
    Conserved Domains (2) summary
    TIGR02169
    Location:75155
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    cd18930
    Location:32111
    bHLHzip_MXI1; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-interacting protein 1 (MXI1) and similar proteins
  5. NM_001360347.1NP_001347276.1  max-interacting protein 1 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (c) is shorter and has a distinct N-terminus, compared to isoform a. This variant is supported by mRNAs and ESTs but the existence of the protein product has not been verified experimentally. Variants 3-6 encode the same protein.
    Source sequence(s)
    AC133451
    Consensus CDS
    CCDS38023.1
    Related
    ENSMUSP00000157400.2, ENSMUST00000236973.2
    Conserved Domains (2) summary
    TIGR02169
    Location:75155
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    cd18930
    Location:32111
    bHLHzip_MXI1; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-interacting protein 1 (MXI1) and similar proteins
  6. NM_001360348.1NP_001347277.1  max-interacting protein 1 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (d) is longer and has a distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AC133451
    Conserved Domains (2) summary
    smart00353
    Location:80132
    HLH; helix loop helix domain
    cl25732
    Location:118198
    SMC_N; RecF/RecN/SMC N terminal domain
  7. NM_010847.4NP_034977.1  max-interacting protein 1 isoform a

    See identical proteins and their annotated locations for NP_034977.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), also referred to as SRbeta, encodes the predominant isoform (a).
    Source sequence(s)
    AC133451, AK140465, CJ170779
    Consensus CDS
    CCDS29901.1
    UniProtKB/Swiss-Prot
    P50540
    UniProtKB/TrEMBL
    Q3USD3
    Related
    ENSMUSP00000107366.3, ENSMUST00000111737.3
    Conserved Domains (1) summary
    smart00353
    Location:73125
    HLH; helix loop helix domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    53298509..53361724
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526735.5XP_006526798.1  max-interacting protein 1 isoform X1

    Conserved Domains (2) summary
    TIGR02169
    Location:168248
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    cl00081
    Location:125204
    bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
  2. XM_006526739.2XP_006526802.1  max-interacting protein 1 isoform X3

    See identical proteins and their annotated locations for XP_006526802.1

    UniProtKB/Swiss-Prot
    P50540
    Related
    ENSMUSP00000157822.2, ENSMUST00000237480.2
    Conserved Domains (2) summary
    TIGR02169
    Location:75155
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    cd18930
    Location:32111
    bHLHzip_MXI1; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-interacting protein 1 (MXI1) and similar proteins
  3. XM_030250763.1XP_030106623.1  max-interacting protein 1 isoform X2

    Conserved Domains (2) summary
    PRK00286
    Location:10186
    xseA; exodeoxyribonuclease VII large subunit; Reviewed
    cl00081
    Location:58137
    bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
  4. XM_030250765.1XP_030106625.1  max-interacting protein 1 isoform X3

    Related
    ENSMUSP00000157790.2, ENSMUST00000235880.2
    Conserved Domains (2) summary
    TIGR02169
    Location:75155
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    cd18930
    Location:32111
    bHLHzip_MXI1; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-interacting protein 1 (MXI1) and similar proteins
  5. XM_030250764.2XP_030106624.1  max-interacting protein 1 isoform X3

    Conserved Domains (2) summary
    TIGR02169
    Location:75155
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    cd18930
    Location:32111
    bHLHzip_MXI1; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-interacting protein 1 (MXI1) and similar proteins
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