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egl-8 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase;1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8;Phosphoinositide phospholipase C [ Caenorhabditis elegans ]

Gene ID: 178537, updated on 10-Oct-2019

Summary

Gene symbol
egl-8
Gene description
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase;1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8;Phosphoinositide phospholipase C
Primary source
WormBase:WBGene00001177
Locus tag
CELE_B0348.4
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis

Genomic context

See egl-8 in Genome Data Viewer
Location:
chromosome: V
Exon count:
24
Sequence:
Chromosome: V; NC_003283.11 (20825..55451)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene LITAF domain-containing protein Neighboring gene LITAF domain-containing protein Neighboring gene Serpentine Receptor, class T Neighboring gene CYtochrome P450 family Neighboring gene hypothetical protein

Bibliography

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol phospholipase C activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol phospholipase C activity IEA
Inferred from Electronic Annotation
more info
 
phosphoric diester hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
chemotaxis IGI
Inferred from Genetic Interaction
more info
PubMed 
dopamine receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
inositol trisphosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of acetylcholine secretion, neurotransmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of axon regeneration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of locomotion IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein localization to synapse IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of locomotion IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of oviposition IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of pharyngeal pumping IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of pharyngeal pumping IMP
Inferred from Mutant Phenotype
more info
PubMed 
release of sequestered calcium ion into cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
thermotaxis IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
adherens junction IEA
Inferred from Electronic Annotation
more info
 
axon IEA
Inferred from Electronic Annotation
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cell projection IEA
Inferred from Electronic Annotation
more info
 
perikaryon IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase;1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8;Phosphoinositide phospholipase C
NP_001021346.1
  • Confirmed by transcript evidence
NP_001021347.1
  • Confirmed by transcript evidence
NP_001021348.1
  • Confirmed by transcript evidence
NP_001300014.1
  • Confirmed by transcript evidence
NP_001300016.1
  • Confirmed by transcript evidence
NP_001300018.1
  • Confirmed by transcript evidence
NP_001300020.1
  • Confirmed by transcript evidence
NP_001300022.1
  • Confirmed by transcript evidence
NP_001300024.1
  • Confirmed by transcript evidence
NP_001300026.1
  • Confirmed by transcript evidence
NP_001300028.1
  • Confirmed by transcript evidence
NP_001300030.1
  • Confirmed by transcript evidence
NP_001300032.1
  • Confirmed by transcript evidence
NP_001300034.1
  • Confirmed by transcript evidence
NP_001360387.1
  • Confirmed by transcript evidence
NP_001360388.1
  • Confirmed by transcript evidence
NP_001360389.1
  • Confirmed by transcript evidence
NP_001360390.1
  • Confirmed by transcript evidence
NP_001360391.1
  • Confirmed by transcript evidence
NP_001360392.1
  • Confirmed by transcript evidence
NP_001360393.1
  • Confirmed by transcript evidence
NP_001360394.1
  • Confirmed by transcript evidence
NP_001360395.1
  • Confirmed by transcript evidence
NP_001360396.1
  • Confirmed by transcript evidence
NP_001360397.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    20825..55451
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001372988.1NP_001360397.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase [Caenorhabditis elegans]

    Status: REVIEWED

  2. NM_001372978.1NP_001360387.1  Phosphoinositide phospholipase C [Caenorhabditis elegans]

    Status: REVIEWED

  3. NM_001026175.4NP_001021346.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021346.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EBH0
    Conserved Domains (8) summary
    cd00275
    Location:8951015
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:339495
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    PLN02952
    Location:218994
    PLN02952; phosphoinositide phospholipase C
    cd13361
    Location:17142
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam06631
    Location:11211163
    DUF1154; Protein of unknown function (DUF1154)
    pfam08703
    Location:12771418
    PLC-beta_C; PLC-beta C terminal
    pfam09279
    Location:249339
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    cl14615
    Location:758861
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
  4. NM_001372979.1NP_001360388.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase [Caenorhabditis elegans]

    Status: REVIEWED

  5. NM_001372980.1NP_001360389.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase [Caenorhabditis elegans]

    Status: REVIEWED

  6. NM_001372981.1NP_001360390.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase [Caenorhabditis elegans]

    Status: REVIEWED

  7. NM_001372982.1NP_001360391.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase [Caenorhabditis elegans]

    Status: REVIEWED

  8. NM_001372983.1NP_001360392.1  Phosphoinositide phospholipase C [Caenorhabditis elegans]

    Status: REVIEWED

  9. NM_001372984.1NP_001360393.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase [Caenorhabditis elegans]

    Status: REVIEWED

  10. NM_001372985.1NP_001360394.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase [Caenorhabditis elegans]

    Status: REVIEWED

  11. NM_001372986.1NP_001360395.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase [Caenorhabditis elegans]

    Status: REVIEWED

  12. NM_001372987.1NP_001360396.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase [Caenorhabditis elegans]

    Status: REVIEWED

  13. NM_001313085.2NP_001300014.1  Phosphoinositide phospholipase C [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AXH8
    Conserved Domains (7) summary
    cd00275
    Location:9761096
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:339495
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17142
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam06631
    Location:12021244
    DUF1154; Protein of unknown function (DUF1154)
    pfam08703
    Location:13701511
    PLC-beta_C; PLC-beta C terminal
    pfam09279
    Location:249339
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    cl14615
    Location:839942
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
  14. NM_001026176.3NP_001021347.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021347.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EBH0
    Conserved Domains (8) summary
    cd00275
    Location:8951015
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:339495
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    PLN02952
    Location:218994
    PLN02952; phosphoinositide phospholipase C
    cd13361
    Location:17142
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam06631
    Location:11211163
    DUF1154; Protein of unknown function (DUF1154)
    pfam08703
    Location:12891430
    PLC-beta_C; PLC-beta C terminal
    pfam09279
    Location:249339
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    cl14615
    Location:758861
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
  15. NM_001313087.2NP_001300016.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AUL3
    Conserved Domains (8) summary
    cd00275
    Location:870990
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:339495
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    PLN02952
    Location:218969
    PLN02952; phosphoinositide phospholipase C
    cd13361
    Location:17142
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam06631
    Location:10961138
    DUF1154; Protein of unknown function (DUF1154)
    pfam08703
    Location:12641405
    PLC-beta_C; PLC-beta C terminal
    pfam09279
    Location:249339
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    cl14615
    Location:733836
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
  16. NM_001313089.2NP_001300018.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AV83
    Conserved Domains (7) summary
    cd00275
    Location:789909
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:339755
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    PLN02952
    Location:218888
    PLN02952; phosphoinositide phospholipase C
    cd13361
    Location:17142
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam06631
    Location:10151057
    DUF1154; Protein of unknown function (DUF1154)
    pfam08703
    Location:11831324
    PLC-beta_C; PLC-beta C terminal
    pfam09279
    Location:249335
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
  17. NM_001313091.2NP_001300020.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AS74
    Conserved Domains (7) summary
    cd00275
    Location:810930
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:339776
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    PLN02952
    Location:218909
    PLN02952; phosphoinositide phospholipase C
    cd13361
    Location:17142
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam06631
    Location:10361078
    DUF1154; Protein of unknown function (DUF1154)
    pfam08703
    Location:12041345
    PLC-beta_C; PLC-beta C terminal
    pfam09279
    Location:249339
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
  18. NM_001313093.2NP_001300022.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3ARR2
    Conserved Domains (7) summary
    cd00275
    Location:729849
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:339695
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    PLN02228
    Location:205840
    PLN02228; Phosphoinositide phospholipase C
    cd13361
    Location:17142
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam06631
    Location:955997
    DUF1154; Protein of unknown function (DUF1154)
    pfam08703
    Location:11231264
    PLC-beta_C; PLC-beta C terminal
    pfam09279
    Location:249339
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
  19. NM_001313095.2NP_001300024.1  Phosphoinositide phospholipase C [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AXJ0
    Conserved Domains (7) summary
    cd00275
    Location:9481068
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:311467
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17142
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam06631
    Location:11741216
    DUF1154; Protein of unknown function (DUF1154)
    pfam08703
    Location:13421483
    PLC-beta_C; PLC-beta C terminal
    pfam09279
    Location:221307
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    cl14615
    Location:811914
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
  20. NM_001313097.2NP_001300026.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AUM3
    Conserved Domains (8) summary
    cd00275
    Location:867987
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:311467
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    PLN02952
    Location:206966
    PLN02952; phosphoinositide phospholipase C
    cd13361
    Location:17142
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam06631
    Location:10931135
    DUF1154; Protein of unknown function (DUF1154)
    pfam08703
    Location:12611402
    PLC-beta_C; PLC-beta C terminal
    pfam09279
    Location:221307
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    cl14615
    Location:730833
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
  21. NM_001313099.2NP_001300028.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AV97
    Conserved Domains (8) summary
    cd00275
    Location:842962
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:311467
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    PLN02952
    Location:206941
    PLN02952; phosphoinositide phospholipase C
    cd13361
    Location:17142
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam06631
    Location:10681110
    DUF1154; Protein of unknown function (DUF1154)
    pfam08703
    Location:12361377
    PLC-beta_C; PLC-beta C terminal
    pfam09279
    Location:221307
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    cl14615
    Location:705808
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
  22. NM_001313101.2NP_001300030.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AS85
    Conserved Domains (7) summary
    cd00275
    Location:761881
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:311727
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    PLN02952
    Location:206860
    PLN02952; phosphoinositide phospholipase C
    cd13361
    Location:17142
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam06631
    Location:9871029
    DUF1154; Protein of unknown function (DUF1154)
    pfam08703
    Location:11551296
    PLC-beta_C; PLC-beta C terminal
    pfam09279
    Location:221311
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
  23. NM_001313103.2NP_001300032.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3ARS4
    Conserved Domains (7) summary
    cd00275
    Location:782902
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:311748
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    PLN02952
    Location:206881
    PLN02952; phosphoinositide phospholipase C
    cd13361
    Location:17142
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam06631
    Location:10081050
    DUF1154; Protein of unknown function (DUF1154)
    pfam08703
    Location:11761317
    PLC-beta_C; PLC-beta C terminal
    pfam09279
    Location:221311
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
  24. NM_001313105.2NP_001300034.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AXK2
    Conserved Domains (7) summary
    cd00275
    Location:701821
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:311667
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    PLN02228
    Location:218812
    PLN02228; Phosphoinositide phospholipase C
    cd13361
    Location:17142
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam06631
    Location:927969
    DUF1154; Protein of unknown function (DUF1154)
    pfam08703
    Location:10951236
    PLC-beta_C; PLC-beta C terminal
    pfam09279
    Location:221311
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
  25. NM_001026177.4NP_001021348.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021348.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EBH0
    Conserved Domains (3) summary
    cd08591
    Location:339495
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17142
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam09279
    Location:249335
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
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