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itsn-1 ITSN (intersectin) family [ Caenorhabditis elegans ]

Gene ID: 178491, updated on 5-Sep-2019

Summary

Gene symbol
itsn-1
Gene description
ITSN (intersectin) family
Primary source
WormBase:WBGene00006405
Locus tag
CELE_Y116A8C.36
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis

Genomic context

See itsn-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
8
Sequence:
Chromosome: IV; NC_003282.8 (17119684..17126275)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene WSN domain-containing protein Neighboring gene Peptidyl-prolyl cis-trans isomerase;Peptidyl-prolyl cis-trans isomerase E Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene U2AF splicing factor Neighboring gene ncRNA Neighboring gene Tyrosine-protein phosphatase domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

Bibliography

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
positive regulation of synaptic vesicle endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
endocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
presynaptic periactive zone IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ITSN (intersectin) family
NP_001255927.1
  • Product from WormBase gene class itsn;
    Confirmed by transcript evidence
NP_001255928.1
  • Product from WormBase gene class itsn;
    Confirmed by transcript evidence
NP_001255929.1
  • Product from WormBase gene class itsn;
    Partially confirmed by transcript evidence
NP_001299978.1
  • Product from WormBase gene class itsn;
    Partially confirmed by transcript evidence
NP_001299979.1
  • Product from WormBase gene class itsn;
    Partially confirmed by transcript evidence
NP_001299980.1
  • Product from WormBase gene class itsn;
    Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    17119684..17126275
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001313049.2NP_001299978.1  ITSN (intersectin) family [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AS36
    Conserved Domains (9) summary
    smart00027
    Location:493
    EH; Eps15 homology domain
    cd11836
    Location:667721
    SH3_Intersectin_1; First Src homology 3 domain (or SH3A) of Intersectin
    cd11837
    Location:786838
    SH3_Intersectin_2; Second Src homology 3 domain (or SH3B) of Intersectin
    cd11839
    Location:9651021
    SH3_Intersectin_4; Fourth Src homology 3 domain (or SH3D) of Intersectin
    smart00326
    Location:10281085
    SH3; Src homology 3 domains
    cd00052
    Location:180246
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    pfam09798
    Location:390429
    LCD1; DNA damage checkpoint protein
    pfam14988
    Location:387578
    DUF4515; Domain of unknown function (DUF4515)
    cl21478
    Location:423544
    ATP-synt_B; ATP synthase B/B' CF(0)
  2. NM_001268998.2NP_001255927.1  ITSN (intersectin) family [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255927.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9U2T9
    Conserved Domains (9) summary
    smart00027
    Location:493
    EH; Eps15 homology domain
    cd11836
    Location:665719
    SH3_Intersectin_1; First Src homology 3 domain (or SH3A) of Intersectin
    cd11837
    Location:784836
    SH3_Intersectin_2; Second Src homology 3 domain (or SH3B) of Intersectin
    cd11839
    Location:9631019
    SH3_Intersectin_4; Fourth Src homology 3 domain (or SH3D) of Intersectin
    smart00326
    Location:10261083
    SH3; Src homology 3 domains
    cd00052
    Location:180246
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    pfam09798
    Location:390429
    LCD1; DNA damage checkpoint protein
    pfam14988
    Location:387576
    DUF4515; Domain of unknown function (DUF4515)
    cl21478
    Location:459564
    ATP-synt_B; ATP synthase B/B' CF(0)
  3. NM_001313050.2NP_001299979.1  ITSN (intersectin) family [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AUH0
    Conserved Domains (6) summary
    cd11836
    Location:407461
    SH3_Intersectin_1; First Src homology 3 domain (or SH3A) of Intersectin
    cd11837
    Location:526578
    SH3_Intersectin_2; Second Src homology 3 domain (or SH3B) of Intersectin
    cd11839
    Location:705761
    SH3_Intersectin_4; Fourth Src homology 3 domain (or SH3D) of Intersectin
    smart00326
    Location:768825
    SH3; Src homology 3 domains
    pfam09798
    Location:130169
    LCD1; DNA damage checkpoint protein
    cl21478
    Location:163284
    ATP-synt_B; ATP synthase B/B' CF(0)
  4. NM_001268999.2NP_001255928.1  ITSN (intersectin) family [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255928.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E6N0W0
    Conserved Domains (6) summary
    cd11836
    Location:405459
    SH3_Intersectin_1; First Src homology 3 domain (or SH3A) of Intersectin
    cd11837
    Location:524576
    SH3_Intersectin_2; Second Src homology 3 domain (or SH3B) of Intersectin
    cd11839
    Location:703759
    SH3_Intersectin_4; Fourth Src homology 3 domain (or SH3D) of Intersectin
    smart00326
    Location:766823
    SH3; Src homology 3 domains
    pfam09798
    Location:130169
    LCD1; DNA damage checkpoint protein
    cl21478
    Location:199304
    ATP-synt_B; ATP synthase B/B' CF(0)
  5. NM_001269000.2NP_001255929.1  ITSN (intersectin) family [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255929.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E6N0W1
    Conserved Domains (5) summary
    cd11836
    Location:212266
    SH3_Intersectin_1; First Src homology 3 domain (or SH3A) of Intersectin
    cd11837
    Location:331383
    SH3_Intersectin_2; Second Src homology 3 domain (or SH3B) of Intersectin
    cd11839
    Location:510566
    SH3_Intersectin_4; Fourth Src homology 3 domain (or SH3D) of Intersectin
    smart00326
    Location:573630
    SH3; Src homology 3 domains
    cl21478
    Location:6111
    ATP-synt_B; ATP synthase B/B' CF(0)
  6. NM_001313051.2NP_001299980.1  ITSN (intersectin) family [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3ARL5
    Conserved Domains (4) summary
    cd11836
    Location:214268
    SH3_Intersectin_1; First Src homology 3 domain (or SH3A) of Intersectin
    cd11837
    Location:333385
    SH3_Intersectin_2; Second Src homology 3 domain (or SH3B) of Intersectin
    cd11839
    Location:512568
    SH3_Intersectin_4; Fourth Src homology 3 domain (or SH3D) of Intersectin
    smart00326
    Location:575632
    SH3; Src homology 3 domains
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