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rho-1 Ras-like GTP-binding protein rhoA [ Caenorhabditis elegans ]

Gene ID: 178458, updated on 18-Sep-2024

Summary

Official Symbol
rho-1
Official Full Name
Ras-like GTP-binding protein rhoA
Primary source
WormBase:WBGene00004357
Locus tag
CELE_Y51H4A.3
See related
AllianceGenome:WB:WBGene00004357
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables several functions, including GTP binding activity; GTPase activating protein binding activity; and GTPase activity. Involved in several processes, including actomyosin structure organization; positive regulation of acetylcholine secretion, neurotransmission; and positive regulation of locomotion. Located in cell cortex and cleavage furrow. Is expressed in several structures, including germ line. Human ortholog(s) of this gene implicated in breast carcinoma. Orthologous to several human genes including RHOA (ras homolog family member A). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See rho-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
4
Sequence:
Chromosome: IV; NC_003282.8 (16482781..16489021, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene High mobility group protein HMG-I/HMG-Y Neighboring gene ncRNA Neighboring gene BZIP domain-containing protein

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activating protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in actomyosin contractile ring assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in myosin filament assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in organelle organization IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of acetylcholine secretion, neurotransmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of locomotion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of actin filament-based process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of actin filament-based process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in skeletal muscle myosin thick filament assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell cortex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
 
located_in cleavage furrow IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Ras-like GTP-binding protein rhoA
NP_502959.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    16482781..16489021 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_070558.9NP_502959.1  Ras-like GTP-binding protein rhoA [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_502959.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q22038
    Conserved Domains (1) summary
    cd01870
    Location:5179
    RhoA_like; Ras homology family A (RhoA)-like includes RhoA, RhoB and RhoC

RNA

  1. NR_131670.1 RNA Sequence

    Status: REVIEWED