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Muc2 mucin 2 [ Mus musculus (house mouse) ]

Gene ID: 17831, updated on 8-Feb-2024

Summary

Official Symbol
Muc2provided by MGI
Official Full Name
mucin 2provided by MGI
Primary source
MGI:MGI:1339364
See related
Ensembl:ENSMUSG00000025515 AllianceGenome:MGI:1339364
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MCM; wnn; 2010015E03Rik
Summary
Predicted to enable identical protein binding activity. Acts upstream of or within several processes, including epithelial cell development; negative regulation of cell migration; and positive regulation of apoptotic process. Located in extracellular matrix; inner mucus layer; and outer mucus layer. Is expressed in ileum and intestine. Used to study inflammatory bowel disease. Human ortholog(s) of this gene implicated in asthma. Orthologous to human MUC2 (mucin 2, oligomeric mucus/gel-forming). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in colon adult (RPKM 1294.7), large intestine adult (RPKM 306.2) and 2 other tissues See more
Orthologs
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Genomic context

See Muc2 in Genome Data Viewer
Location:
7 F5; 7 87.1 cM
Exon count:
48
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (141276583..141308428)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (141690340..141754691)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene adaptor-related protein complex 2, alpha 2 subunit Neighboring gene microRNA 7063 Neighboring gene mucin 6, gastric Neighboring gene mucin 5, subtypes A and C, tracheobronchial/gastric Neighboring gene STARR-seq mESC enhancer starr_20496 Neighboring gene mucin 5, subtype B, tracheobronchial

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cupric ion binding ISO
Inferred from Sequence Orthology
more info
 
enables cuprous ion binding ISO
Inferred from Sequence Orthology
more info
 
enables extracellular matrix structural constituent IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix HDA PubMed 
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in inner mucus layer IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in mucus layer IDA
Inferred from Direct Assay
more info
PubMed 
located_in mucus layer ISO
Inferred from Sequence Orthology
more info
 
located_in outer mucus layer IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
mucin-2
Names
colonic mucin
secreted gel-forming mucin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023566.4NP_076055.4  mucin-2 precursor

    Status: VALIDATED

    Source sequence(s)
    LXEJ02004842
    UniProtKB/Swiss-Prot
    A0A087WSG8, Q0P637, Q80Z17, Q80Z19, Q8K0Q1, Q9CVG8, Q9Z2U5
    Related
    ENSMUSP00000141040.3, ENSMUST00000185406.8
    Conserved Domains (9) summary
    smart00041
    Location:44744553
    CT; C-terminal cystine knot-like domain (CTCK)
    smart00214
    Location:43224386
    VWC; von Willebrand factor (vWF) type C domain
    smart00216
    Location:8481006
    VWD; von Willebrand factor (vWF) type D domain
    smart00832
    Location:580649
    C8; This domain contains 8 conserved cysteine residues
    pfam00094
    Location:389543
    VWD; von Willebrand factor type D domain
    pfam08742
    Location:40894151
    C8; C8 domain
    pfam13330
    Location:13001382
    Mucin2_WxxW; Mucin-2 protein WxxW repeating region
    pfam17061
    Location:35533644
    PARM
    cd19941
    Location:293349
    TIL; trypsin inhibitor-like cysteine rich domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    141276583..141308428
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)