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unc-26 Synaptojanin [ Caenorhabditis elegans ]

Gene ID: 178284, updated on 22-Aug-2021

Summary

Gene symbol
unc-26
Gene description
Synaptojanin
Primary source
WormBase:WBGene00006763
Locus tag
CELE_JC8.10
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
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Genomic context

See unc-26 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
10
Sequence:
Chromosome: IV; NC_003282.8 (13261555..13272516, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene TransThyretin-Related family domain Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene Cleavage and Polyadenylation Specificity Factor Neighboring gene Uncharacterized protein

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in Golgi vesicle uncoating IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in acetylcholine transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in endosome organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in gamma-aminobutyric acid transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in inositol phosphate dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in locomotion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phosphatidylinositol dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phosphatidylinositol dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in phosphatidylinositol-3-phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of necrotic cell death IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of neurotransmitter secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization to synapse IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of backward locomotion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of forward locomotion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in synaptic vesicle budding from presynaptic endocytic zone membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in synaptic vesicle endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in synaptic vesicle endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in synaptic vesicle transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in synaptic vesicle uncoating IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vesicle organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 
located_in synaptic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in synaptic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

General protein information

Preferred Names
Synaptojanin
NP_001023265.1
  • Confirmed by transcript evidence
NP_001023266.1
  • Confirmed by transcript evidence
NP_001122785.1
  • Confirmed by transcript evidence
NP_001129862.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    13261555..13272516 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001028094.5NP_001023265.1  Synaptojanin [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023265.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5ECL2
    Conserved Domains (3) summary
    cd09089
    Location:521829
    INPP5c_Synj; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanins
    pfam02383
    Location:60336
    Syja_N; SacI homology domain
    cl17169
    Location:844972
    RRM_SF; RNA recognition motif (RRM) superfamily
  2. NM_001028095.6NP_001023266.1  Synaptojanin [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023266.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5ECL2
    Conserved Domains (3) summary
    cd09089
    Location:527835
    INPP5c_Synj; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanins
    pfam02383
    Location:60336
    Syja_N; SacI homology domain
    cl17169
    Location:850978
    RRM_SF; RNA recognition motif (RRM) superfamily
  3. NM_001136390.4NP_001129862.1  Synaptojanin [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001129862.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5ECL2
    Conserved Domains (1) summary
    pfam02383
    Location:60336
    Syja_N; SacI homology domain
  4. NM_001129313.3NP_001122785.1  Synaptojanin [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122785.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5ECL2
    Conserved Domains (1) summary
    pfam02383
    Location:60336
    Syja_N; SacI homology domain
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