Mtx1 metaxin 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mtx1provided by MGI
Official Full Name: metaxin 1provided by MGI
Primary source: MGI:MGI:103025
See related: Ensembl:ENSMUSG00000064068 AllianceGenome:MGI:103025
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mtx; Gcap6
Summary: Predicted to be involved in mitochondrion organization. Predicted to act upstream of or within protein transport. Located in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; cerebral cortex ventricular layer; liver lobe; pharyngo-tympanic tube; and skin. Orthologous to human MTX1 (metaxin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 88.2), adrenal adult (RPKM 34.8) and 28 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 3 F1; 3 39.01 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (89116388..89121214, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (89209081..89213907, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The alteration of the mitochondrial outer membrane properties by metaxin deficiency and Bcl-X(L) overexpression, as indicated by a quicker Rh123 release, may be helpful in maintaining mitochondrial integrity
Title: Metaxin deficiency alters mitochondrial membrane permeability and leads to resistance to TNF-induced cell killing.

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

Gba (e-PCR), detects polymorphism
- UniSTS:143180

AI464196 (e-PCR)
- UniSTS:165266

NoName (e-PCR)
- UniSTS:234730

Homology

Homologs of the Mtx1 gene: The Mtx1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, zebrafish, fruit fly, mosquito, and C.elegans.
Orthologs from Annotation Pipeline: 303 organisms have orthologs with human gene Mtx1
Orthologs

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in mitochondrion organization	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of SAM complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of SAM complex	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	HDA more info	PubMed
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: metaxin-1

Names: mitochondrial outer membrane import complex protein 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001161824.2 → NP_001155296.2 metaxin-1 isoform 2

Status: VALIDATED

Source sequence(s)

AC161600

Related

ENSMUSP00000133282.2, ENSMUST00000173477.8

Conserved Domains (2) summary

cd03212
Location:105 → 241

GST_C_Metaxin1_3; C-terminal, alpha helical domain of Metaxin 1, Metaxin 3, and similar proteins

pfam10568
Location:23 → 143

Tom37; Outer mitochondrial membrane transport complex protein
NM_001357367.2 → NP_001344296.2 metaxin-1 isoform 3

Status: VALIDATED

Source sequence(s)

AC161600

UniProtKB/TrEMBL

D3Z3F4

Related

ENSMUSP00000113986.3, ENSMUST00000119222.9

Conserved Domains (2) summary

cd03212
Location:144 → 280

GST_C_Metaxin1_3; C-terminal, alpha helical domain of Metaxin 1, Metaxin 3, and similar proteins

pfam10568
Location:23 → 182

Tom37; Outer mitochondrial membrane transport complex protein
NM_013604.3 → NP_038632.3 metaxin-1 isoform 1

Status: VALIDATED

Source sequence(s)

AC161600

Consensus CDS

CCDS17494.2

UniProtKB/TrEMBL

F7C846

Related

ENSMUSP00000073261.6, ENSMUST00000073572.12

Conserved Domains (2) summary

cd03212
Location:106 → 242

GST_C_Metaxin1_3; C-terminal, alpha helical domain of Metaxin 1, Metaxin 3, and similar proteins

pfam10568
Location:23 → 144

Tom37; Outer mitochondrial membrane transport complex protein