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rib-1 Exostosin-1 homolog [ Caenorhabditis elegans ]

Gene ID: 178080, updated on 4-Feb-2026
Official Symbol
rib-1
Official Full Name
Exostosin-1 homolog
Primary source
WormBase:WBGene00004360
Locus tag
CELE_F12F6.3
See related
AllianceGenome:WB:WBGene00004360
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables enzyme binding activity. Contributes to acetylglucosaminyltransferase activity and glucuronosyltransferase activity. Involved in heparan sulfate proteoglycan biosynthetic process and nematode pharynx development. Part of protein-containing complex. Is expressed in alimentary muscle; alimentary system; hypodermal cell; nervous system; and reproductive system. Used to study hereditary multiple exostoses. Human ortholog(s) of this gene implicated in chondrosarcoma and hereditary multiple exostoses. Orthologous to several human genes including EXTL1 (exostosin like glycosyltransferase 1). [provided by Alliance of Genome Resources, Jul 2025]
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See rib-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
10
Sequence:
Chromosome: IV; NC_003282.8 (11578792..11583841)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Rho-GAP domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene BEN domain-containing protein Neighboring gene EGF-like calcium-binding domain-containing protein Neighboring gene BOD1/SHG1 domain-containing protein Neighboring gene ncRNA

Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Functional Requirements for Heparan Sulfate Biosynthesis in Morphogenesis and Nervous System Development in C. elegans. Blanchette CR, et al. PLoS Genet, 2017 Jan. PMID 28068429, Free PMC Article
  2. rib-2, a Caenorhabditis elegans homolog of the human tumor suppressor EXT genes encodes a novel alpha1,4-N-acetylglucosaminyltransferase involved in the biosynthetic initiation and elongation of heparan sulfate. Kitagawa H, et al. J Biol Chem, 2001 Feb 16. PMID 11121397
  3. A genetic screen for temperature-sensitive morphogenesis-defective Caenorhabditis elegans mutants. Jud MC, et al. G3 (Bethesda), 2021 Apr 15. PMID 33713117, Free PMC Article
  4. Expression of rib-1, a Caenorhabditis elegans homolog of the human tumor suppressor EXT genes, is indispensable for heparan sulfate synthesis and embryonic morphogenesis. Kitagawa H, et al. J Biol Chem, 2007 Mar 16. PMID 17237233
  5. Syndecan defines precise spindle orientation by modulating Wnt signaling in C. elegans. Dejima K, et al. Development, 2014 Nov. PMID 25344071, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
contributes_to acetylglucosaminyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
contributes_to glucuronosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glycosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glycoprotein biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in heparan sulfate proteoglycan biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in heparan sulfate proteoglycan biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in heparan sulfate proteoglycan biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in heparan sulfate proteoglycan biosynthetic process IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in nematode pharynx development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
Exostosin-1 homolog
NP_001293963.1
  • Confirmed by transcript evidence
NP_502180.1
  • Confirmed by transcript evidence

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    11578792..11583841
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069779.6 → NP_502180.1  Exostosin-1 homolog

    See identical proteins and their annotated locations for NP_502180.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4F1W7, O01704, Q9U3J6
    Conserved Domains (1) summary
    pfam03016
    Location:46 → 333
    Exostosin; Exostosin family

  2. NM_001307034.3 → NP_001293963.1  Exostosin-1 homolog

    See identical proteins and their annotated locations for NP_001293963.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A061AKX1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O01704.2

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