klp-12 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: klp-12
Primary source: WormBase:WBGene00002223
Locus tag: CELE_T01G1.1
See related: AllianceGenome:WB:WBGene00002223
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Predicted to be involved in microtubule-based movement. Predicted to be located in cytoskeleton. Predicted to be part of kinesin complex. Predicted to be active in microtubule. Is expressed in head. Human ortholog(s) of this gene implicated in congenital fibrosis of the extraocular muscles 1. Orthologous to several human genes including KIF21B (kinesin family member 21B). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: IV

Exon count:: 21

Sequence:: Chromosome: IV; NC_003282.8 (11341325..11359869, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T01G1.1 (e-PCR)
- UniSTS:311621

T01G1.2 (e-PCR)
- UniSTS:317033

STS4-176 (e-PCR)
- UniSTS:242165

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule motor activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in microtubule-based movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule-based movement	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
part_of kinesin complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Kinesin-like protein klp-12

NP_001023349.1

Confirmed by transcript evidence

NP_001122796.1

Confirmed by transcript evidence

NP_001129866.1

Confirmed by transcript evidence

NP_001360493.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

11341325..11359869 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001372925.2 → NP_001360493.1 Kinesin-like protein klp-12 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (6) summary

COG0419
Location:608 → 1026

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

COG1196
Location:598 → 790

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00200
Location:1133 → 1457

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cd01372
Location:4 → 359

KISc_KIF4; Kinesin motor domain, KIF4-like subfamily

sd00039
Location:1144 → 1178

7WD40; WD40 repeat [structural motif]

pfam15921
Location:367 → 791

CCDC158; Coiled-coil domain-containing protein 158
NM_001129324.3 → NP_001122796.1 Kinesin-like protein klp-12 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001122796.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EFJ0

Conserved Domains (6) summary

smart00129
Location:6 → 365

KISc; Kinesin motor, catalytic domain. ATPase

COG2319
Location:1262 → 1578

WD40; WD40 repeat [General function prediction only]

cd00200
Location:1252 → 1576

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cd01372
Location:4 → 359

KISc_KIF4; Kinesin motor domain, KIF4-like subfamily

sd00039
Location:1263 → 1297

7WD40; WD40 repeat [structural motif]

cl21478
Location:609 → 739

ATP-synt_B; ATP synthase B/B' CF(0)
NM_001028178.5 → NP_001023349.1 Kinesin-like protein klp-12 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001023349.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A0A486WUN2, B3GWD7, G5EFJ0, G5EGS3, Q9GRC3

Conserved Domains (6) summary

smart00129
Location:6 → 365

KISc; Kinesin motor, catalytic domain. ATPase

COG2319
Location:1287 → 1603

WD40; WD40 repeat [General function prediction only]

cd00200
Location:1277 → 1601

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cd01372
Location:4 → 359

KISc_KIF4; Kinesin motor domain, KIF4-like subfamily

sd00039
Location:1288 → 1322

7WD40; WD40 repeat [structural motif]

cl21478
Location:609 → 739

ATP-synt_B; ATP synthase B/B' CF(0)
NM_001136394.4 → NP_001129866.1 Kinesin-like protein klp-12 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001129866.1

Status: REVIEWED

UniProtKB/TrEMBL

B3GWD7

Conserved Domains (2) summary

sd00039
Location:20 → 54

7WD40; WD40 repeat [structural motif]

cl29593
Location:9 → 333

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...