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T25B9.9 6-phosphogluconate dehydrogenase, decarboxylating [ Caenorhabditis elegans ]

Gene ID: 177971, updated on 7-Sep-2023

Summary

Gene symbol
T25B9.9
Gene description
6-phosphogluconate dehydrogenase, decarboxylating
Primary source
WormBase:WBGene00012015
Locus tag
CELE_T25B9.9
See related
AllianceGenome:WB:WBGene00012015
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable NADP binding activity and phosphogluconate dehydrogenase (decarboxylating) activity. Involved in defense response to Gram-negative bacterium and negative regulation of gene expression. Predicted to be active in cytosol. Orthologous to human PGD (phosphogluconate dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See T25B9.9 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
7
Sequence:
Chromosome: IV; NC_003282.8 (10769653..10777743)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene DUF19 domain-containing protein Neighboring gene Ovule protein Neighboring gene Uncharacterized protein Neighboring gene Inositol polyphosphate-related phosphatase domain-containing protein Neighboring gene Sugar transporter SWEET1 Neighboring gene ncRNA Neighboring gene Serpentine receptor class delta-7

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables NADP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables NADP binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphogluconate dehydrogenase (decarboxylating) activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphogluconate dehydrogenase (decarboxylating) activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in D-gluconate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in D-gluconate metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in defense response to Gram-negative bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in pentose-phosphate shunt IEA
Inferred from Electronic Annotation
more info
 
involved_in pentose-phosphate shunt, oxidative branch IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
6-phosphogluconate dehydrogenase, decarboxylating
NP_501998.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    10769653..10777743
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069597.8NP_501998.1  6-phosphogluconate dehydrogenase, decarboxylating [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501998.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q17761, Q22772
    Conserved Domains (3) summary
    PRK09287
    Location:14474
    PRK09287; 6-phosphogluconate dehydrogenase; Validated
    pfam00393
    Location:179470
    6PGD; 6-phosphogluconate dehydrogenase, C-terminal domain
    pfam03446
    Location:4174
    NAD_binding_2; NAD binding domain of 6-phosphogluconate dehydrogenase