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unc-43 CaMKII_AD domain-containing protein;Calcium/calmodulin-dependent protein kinase type II;Protein kinase domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 177921, updated on 6-Sep-2019

Summary

Gene symbol
unc-43
Gene description
CaMKII_AD domain-containing protein;Calcium/calmodulin-dependent protein kinase type II;Protein kinase domain-containing protein
Primary source
WormBase:WBGene00006779
Locus tag
CELE_K11E8.1
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis

Genomic context

See unc-43 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
24
Sequence:
Chromosome: IV; NC_003282.8 (10324254..10350217, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene hypothetical protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Tyrosine-protein kinase Neighboring gene hypothetical protein Neighboring gene hypothetical protein

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
calcium-dependent protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
calmodulin-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calmodulin-dependent protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
calmodulin-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ion channel binding IPI
Inferred from Physical Interaction
more info
PubMed 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
MAPK cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
medium-term memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-threonine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
axon IEA
Inferred from Electronic Annotation
more info
 
axon cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cell projection IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
perikaryon IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
CaMKII_AD domain-containing protein;Calcium/calmodulin-dependent protein kinase type II;Protein kinase domain-containing protein
NP_001023293.2
  • Partially confirmed by transcript evidence
NP_001023294.1
  • Partially confirmed by transcript evidence
NP_001023298.1
  • Confirmed by transcript evidence
NP_001023303.1
  • Confirmed by transcript evidence
NP_001023304.1
  • Confirmed by transcript evidence
NP_001122788.1
  • Confirmed by transcript evidence
NP_001122789.1
  • Confirmed by transcript evidence
NP_001129863.1
  • Confirmed by transcript evidence
NP_001255480.1
  • Partially confirmed by transcript evidence
NP_001255481.1
  • Confirmed by transcript evidence
NP_001255482.1
  • Confirmed by transcript evidence
NP_001255483.1
  • Confirmed by transcript evidence
NP_001359630.1
  • Confirmed by transcript evidence
NP_001359631.1
  • Confirmed by transcript evidence
NP_001359632.1
  • Confirmed by transcript evidence
NP_001359633.1
  • Confirmed by transcript evidence
NP_001359634.1
  • Confirmed by transcript evidence
NP_001359635.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    10324254..10350217 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001028133.5NP_001023304.1  Calcium/calmodulin-dependent protein kinase type II [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023304.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O62305
    Conserved Domains (1) summary
    pfam08332
    Location:176300
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  2. NM_001268551.2NP_001255480.1  Protein kinase domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255480.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EDZ5
    Conserved Domains (3) summary
    smart00220
    Location:122379
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14086
    Location:120410
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:548672
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  3. NM_001028127.4NP_001023298.1  Calcium/calmodulin-dependent protein kinase type II [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023298.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O62305
    Conserved Domains (3) summary
    smart00220
    Location:12269
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14086
    Location:10300
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:385509
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  4. NM_001372916.1NP_001359634.1  Calcium/calmodulin-dependent protein kinase type II [Caenorhabditis elegans]

    Status: REVIEWED

  5. NM_001372917.1NP_001359631.1  Calcium/calmodulin-dependent protein kinase type II [Caenorhabditis elegans]

    Status: REVIEWED

  6. NM_001372918.1NP_001359633.1  Calcium/calmodulin-dependent protein kinase type II [Caenorhabditis elegans]

    Status: REVIEWED

  7. NM_001372920.1NP_001359632.1  Calcium/calmodulin-dependent protein kinase type II [Caenorhabditis elegans]

    Status: REVIEWED

  8. NM_001268552.2NP_001255481.1  CaMKII_AD domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255481.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    F5GUA8
    Conserved Domains (1) summary
    pfam08332
    Location:133257
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  9. NM_001136391.3NP_001129863.1  Calcium/calmodulin-dependent protein kinase type II [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001129863.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O62305
    Conserved Domains (1) summary
    pfam08332
    Location:83207
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  10. NM_001268553.2NP_001255482.1  CaMKII_AD domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255482.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    F5GUA9
    Conserved Domains (1) summary
    pfam08332
    Location:165289
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  11. NM_001028122.5NP_001023293.2  Calcium/calmodulin-dependent protein kinase type II [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023293.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O62305
    Conserved Domains (1) summary
    pfam08332
    Location:97221
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  12. NM_001129317.3NP_001122789.1  Calcium/calmodulin-dependent protein kinase type II [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122789.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O62305
    Conserved Domains (1) summary
    pfam08332
    Location:136260
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  13. NM_001129316.3NP_001122788.1  Calcium/calmodulin-dependent protein kinase type II [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122788.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O62305
    Conserved Domains (1) summary
    pfam08332
    Location:82206
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  14. NM_001268554.2NP_001255483.1  CaMKII_AD domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255483.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E7EM33
    Conserved Domains (1) summary
    cl09109
    Location:194
    NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of ...
  15. NM_001372921.1NP_001359635.1  Calcium/calmodulin-dependent protein kinase type II [Caenorhabditis elegans]

    Status: REVIEWED

  16. NM_001028132.4NP_001023303.1  Calcium/calmodulin-dependent protein kinase type II [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023303.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O62305
    Conserved Domains (2) summary
    smart00220
    Location:12269
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14086
    Location:10300
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
  17. NM_001372922.1NP_001359630.1  Calcium/calmodulin-dependent protein kinase type II [Caenorhabditis elegans]

    Status: REVIEWED

  18. NM_001028123.4NP_001023294.1  Calcium/calmodulin-dependent protein kinase type II [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023294.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O62305
    Conserved Domains (2) summary
    smart00220
    Location:12136
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:10136
    PKc_like; Protein Kinases, catalytic domain
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