U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

aat-1 Large neutral amino acids transporter small subunit 1 [ Caenorhabditis elegans ]

Gene ID: 177793, updated on 12-Jun-2024

Summary

Gene symbol
aat-1
Gene description
Large neutral amino acids transporter small subunit 1
Locus tag
CELE_F27C8.1
See related
AllianceGenome:WB:WBGene00000002
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Contributes to L-amino acid transmembrane transporter activity. Involved in amino acid transmembrane transport. Located in plasma membrane. Part of amino acid transport complex. Is expressed in several structures, including excretory system; nervous system; pharynx; rectal gland cell; and reproductive system. Human ortholog(s) of this gene implicated in cystinuria and lysinuric protein intolerance. Orthologous to several human genes including SLC7A8 (solute carrier family 7 member 8). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See aat-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
8
Sequence:
Chromosome: IV; NC_003282.8 (9599178..9601695, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene N-acetyltransferase domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
contributes_to L-amino acid transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in L-alpha-amino acid transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in amino acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in amino acid transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of amino acid transport complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
Large neutral amino acids transporter small subunit 1
NP_501707.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    9599178..9601695 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069306.7NP_501707.1  Large neutral amino acids transporter small subunit 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501707.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q19834
    Conserved Domains (1) summary
    TIGR00911
    Location:2491
    2A0308; L-type amino acid transporter