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pole-2 putative DNA polymerase epsilon subunit 2 [ Caenorhabditis elegans ]

Gene ID: 177673, updated on 23-Nov-2023

Summary

Gene symbol
pole-2
Gene description
putative DNA polymerase epsilon subunit 2
Primary source
WormBase:WBGene00017237
Locus tag
CELE_F08B4.5
See related
AllianceGenome:WB:WBGene00017237
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA binding activity. Predicted to be involved in DNA-dependent DNA replication and error-prone translesion synthesis. Predicted to be located in nucleus. Predicted to be part of epsilon DNA polymerase complex. Orthologous to human POLE2 (DNA polymerase epsilon 2, accessory subunit). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See pole-2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
11
Sequence:
Chromosome: IV; NC_003282.8 (8682240..8686610, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Secreted protein Neighboring gene Neuropeptide-Like Protein Neighboring gene U1 small nuclear ribonucleoprotein C Neighboring gene Heparan sulfate N-sulfotransferase 1

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA-templated DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in DNA-templated DNA replication IEA
Inferred from Electronic Annotation
more info
 
involved_in error-prone translesion synthesis IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
part_of epsilon DNA polymerase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of epsilon DNA polymerase complex IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear lumen IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
putative DNA polymerase epsilon subunit 2
NP_501489.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    8682240..8686610 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069088.8NP_501489.3  putative DNA polymerase epsilon subunit 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501489.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q19196
    Conserved Domains (2) summary
    pfam04042
    Location:276475
    DNA_pol_E_B; DNA polymerase alpha/epsilon subunit B
    pfam12213
    Location:678
    Dpoe2NT; DNA polymerases epsilon N terminal