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Mtf2 metal response element binding transcription factor 2 [ Mus musculus (house mouse) ]

Gene ID: 17765, updated on 26-Sep-2022

Summary

Official Symbol
Mtf2provided by MGI
Official Full Name
metal response element binding transcription factor 2provided by MGI
Primary source
MGI:MGI:105050
See related
Ensembl:ENSMUSG00000029267 AllianceGenome:MGI:105050
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
M96; Pcl2; 9230112N11Rik
Summary
Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity and methylated histone binding activity. Involved in several processes, including regulation of histone H3-K27 methylation; regulation of transcription by RNA polymerase II; and segment specification. Acts upstream of or within cellular response to leukemia inhibitory factor. Part of ESC/E(Z) complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human MTF2 (metal response element binding transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 8.1), CNS E14 (RPKM 6.6) and 20 other tissues See more
Orthologs
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Genomic context

See Mtf2 in Genome Data Viewer
Location:
5; 5 F
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (108213518..108257085)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (108065660..108109219)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 42150 Neighboring gene ribosomal protein S19, pseudogene 8 Neighboring gene transmembrane p24 trafficking protein 5 Neighboring gene coiled-coil domain containing 18 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC116639

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables methylated histone binding IDA
Inferred from Direct Assay
more info
PubMed 
enables methylated histone binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription corepressor binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of ESC/E(Z) complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
metal-response element-binding transcription factor 2
Names
mPCl2
metal regulatory transcription factor 2
metal response element DNA-binding protein M96
polycomb-like protein 2
ziRF1
zinc-regulated factor 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001253877.1NP_001240806.1  metal-response element-binding transcription factor 2 isoform 2

    See identical proteins and their annotated locations for NP_001240806.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction in the 5' end compared to variant 7, which results in the use of a downstream AUG start codon. The resulting isoform (2) is shorter at the N-terminus compared to isoform 3. Variants 2-6 all encode the same isoform (2).
    Source sequence(s)
    AK031409, AK032819, BC092237, CJ311871
    UniProtKB/Swiss-Prot
    Q02395
    Conserved Domains (3) summary
    cd15578
    Location:254
    PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
    cd15580
    Location:101152
    PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
    pfam14061
    Location:442489
    Mtf2_C; Polycomb-like MTF2 factor 2
  2. NM_001253878.1NP_001240807.1  metal-response element-binding transcription factor 2 isoform 2

    See identical proteins and their annotated locations for NP_001240807.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 7, which results in the use of a downstream AUG start codon. The resulting isoform (2) is shorter at the N-terminus compared to isoform 3. Variants 2-6 all encode the same isoform (2).
    Source sequence(s)
    AK139685, BC092237, CJ311871
    UniProtKB/Swiss-Prot
    Q02395
    Conserved Domains (3) summary
    cd15578
    Location:254
    PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
    cd15580
    Location:101152
    PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
    pfam14061
    Location:442489
    Mtf2_C; Polycomb-like MTF2 factor 2
  3. NM_001253879.1NP_001240808.1  metal-response element-binding transcription factor 2 isoform 2

    See identical proteins and their annotated locations for NP_001240808.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 7, which results in the use of a downstream AUG start codon. The resulting isoform (2) is shorter at the N-terminus compared to isoform 3. Variants 2-6 all encode the same isoform (2).
    Source sequence(s)
    AK030752, AK031409, BC092237, CJ311871
    UniProtKB/Swiss-Prot
    Q02395
    Conserved Domains (3) summary
    cd15578
    Location:254
    PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
    cd15580
    Location:101152
    PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
    pfam14061
    Location:442489
    Mtf2_C; Polycomb-like MTF2 factor 2
  4. NM_001253880.1NP_001240809.1  metal-response element-binding transcription factor 2 isoform 2

    See identical proteins and their annotated locations for NP_001240809.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 7, which results in the use of a downstream AUG start codon. The resulting isoform (2) is shorter at the N-terminus compared to isoform 3. Variants 2-6 all encode the same isoform (2).
    Source sequence(s)
    AK031409, AK137539, BC092237, BC100340, CJ311871
    UniProtKB/Swiss-Prot
    Q02395
    Conserved Domains (3) summary
    cd15578
    Location:254
    PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
    cd15580
    Location:101152
    PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
    pfam14061
    Location:442489
    Mtf2_C; Polycomb-like MTF2 factor 2
  5. NM_001359088.1NP_001346017.1  metal-response element-binding transcription factor 2 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) encodes the longest isoform (3).
    Source sequence(s)
    AC134402
    Conserved Domains (4) summary
    cd15578
    Location:115167
    PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
    cd15580
    Location:214265
    PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
    pfam14061
    Location:555602
    Mtf2_C; Polycomb-like MTF2 factor 2
    cd20450
    Location:56109
    Tudor_MTF2; Tudor domain found in metal-response element-binding transcription factor 2 (MTF2) and similar proteins
  6. NM_001359089.1NP_001346018.1  metal-response element-binding transcription factor 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 7, which results in the use of a downstream AUG start codon. The resulting isoform (2) is shorter at the N-terminus compared to isoform 3. Variants 2-6 all encode the same isoform (2).
    Source sequence(s)
    AC134402
    Conserved Domains (3) summary
    cd15578
    Location:254
    PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
    cd15580
    Location:101152
    PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
    pfam14061
    Location:442489
    Mtf2_C; Polycomb-like MTF2 factor 2
  7. NM_013827.3NP_038855.2  metal-response element-binding transcription factor 2 isoform 1

    See identical proteins and their annotated locations for NP_038855.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) lacks an alternate exon in the 5' end compared to variant 7. The resulting isoform (1) has a shorter and distinct N-terminus compared to isoform 3.
    Source sequence(s)
    AK031409, AK137539, BC092237, CJ311871
    Consensus CDS
    CCDS39201.1
    UniProtKB/Swiss-Prot
    Q02395, Q8BSJ7
    Related
    ENSMUSP00000080278.5, ENSMUST00000081567.11
    Conserved Domains (4) summary
    smart00333
    Location:4595
    TUDOR; Tudor domain
    cd15578
    Location:104156
    PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
    cd15580
    Location:203254
    PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
    pfam14061
    Location:544590
    Mtf2_C; Polycomb-like MTF2 factor 2

RNA

  1. NR_152817.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' end and uses an alternate splice junction in the 3' end compared to variant 7. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC134402, AK137539

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    108213518..108257085
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164857.1XP_036020750.1  metal-response element-binding transcription factor 2 isoform X2

    Conserved Domains (3) summary
    cd15578
    Location:254
    PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
    cd15580
    Location:101152
    PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
    pfam14061
    Location:442489
    Mtf2_C; Polycomb-like MTF2 factor 2
  2. XM_036164854.1XP_036020747.1  metal-response element-binding transcription factor 2 isoform X2

    Conserved Domains (3) summary
    cd15578
    Location:254
    PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
    cd15580
    Location:101152
    PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
    pfam14061
    Location:442489
    Mtf2_C; Polycomb-like MTF2 factor 2
  3. XM_036164865.1XP_036020758.1  metal-response element-binding transcription factor 2 isoform X2

    Conserved Domains (3) summary
    cd15578
    Location:254
    PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
    cd15580
    Location:101152
    PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
    pfam14061
    Location:442489
    Mtf2_C; Polycomb-like MTF2 factor 2
  4. XM_036164861.1XP_036020754.1  metal-response element-binding transcription factor 2 isoform X2

    Conserved Domains (3) summary
    cd15578
    Location:254
    PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
    cd15580
    Location:101152
    PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
    pfam14061
    Location:442489
    Mtf2_C; Polycomb-like MTF2 factor 2
  5. XM_011249412.4XP_011247714.1  metal-response element-binding transcription factor 2 isoform X1

    See identical proteins and their annotated locations for XP_011247714.1

    Conserved Domains (4) summary
    cd15578
    Location:115167
    PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
    cd15580
    Location:214265
    PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
    pfam14061
    Location:555602
    Mtf2_C; Polycomb-like MTF2 factor 2
    cd20450
    Location:56109
    Tudor_MTF2; Tudor domain found in metal-response element-binding transcription factor 2 (MTF2) and similar proteins
  6. XM_036164859.1XP_036020752.1  metal-response element-binding transcription factor 2 isoform X2

    Conserved Domains (3) summary
    cd15578
    Location:254
    PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
    cd15580
    Location:101152
    PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
    pfam14061
    Location:442489
    Mtf2_C; Polycomb-like MTF2 factor 2
  7. XM_036164853.1XP_036020746.1  metal-response element-binding transcription factor 2 isoform X1

    Conserved Domains (4) summary
    cd15578
    Location:115167
    PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
    cd15580
    Location:214265
    PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
    pfam14061
    Location:555602
    Mtf2_C; Polycomb-like MTF2 factor 2
    cd20450
    Location:56109
    Tudor_MTF2; Tudor domain found in metal-response element-binding transcription factor 2 (MTF2) and similar proteins
  8. XM_011249417.4XP_011247719.1  metal-response element-binding transcription factor 2 isoform X3

    Conserved Domains (3) summary
    cd15578
    Location:115167
    PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
    pfam18104
    Location:6095
    Tudor_2; Jumonji domain-containing protein 2A Tudor domain
    cl22851
    Location:214265
    PHD_SF; PHD finger superfamily
  9. XM_036164860.1XP_036020753.1  metal-response element-binding transcription factor 2 isoform X2

    Conserved Domains (3) summary
    cd15578
    Location:254
    PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
    cd15580
    Location:101152
    PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
    pfam14061
    Location:442489
    Mtf2_C; Polycomb-like MTF2 factor 2
  10. XM_030254193.2XP_030110053.1  metal-response element-binding transcription factor 2 isoform X2

    Related
    ENSMUST00000131264.8
    Conserved Domains (3) summary
    cd15578
    Location:254
    PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
    cd15580
    Location:101152
    PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
    pfam14061
    Location:442489
    Mtf2_C; Polycomb-like MTF2 factor 2
  11. XM_030254194.2XP_030110054.1  metal-response element-binding transcription factor 2 isoform X2

    Conserved Domains (3) summary
    cd15578
    Location:254
    PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
    cd15580
    Location:101152
    PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
    pfam14061
    Location:442489
    Mtf2_C; Polycomb-like MTF2 factor 2
  12. XM_036164863.1XP_036020756.1  metal-response element-binding transcription factor 2 isoform X2

    Conserved Domains (3) summary
    cd15578
    Location:254
    PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
    cd15580
    Location:101152
    PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
    pfam14061
    Location:442489
    Mtf2_C; Polycomb-like MTF2 factor 2
  13. XM_036164862.1XP_036020755.1  metal-response element-binding transcription factor 2 isoform X2

    Conserved Domains (3) summary
    cd15578
    Location:254
    PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
    cd15580
    Location:101152
    PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
    pfam14061
    Location:442489
    Mtf2_C; Polycomb-like MTF2 factor 2
  14. XM_030254189.2XP_030110049.1  metal-response element-binding transcription factor 2 isoform X1

    Conserved Domains (4) summary
    cd15578
    Location:115167
    PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
    cd15580
    Location:214265
    PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
    pfam14061
    Location:555602
    Mtf2_C; Polycomb-like MTF2 factor 2
    cd20450
    Location:56109
    Tudor_MTF2; Tudor domain found in metal-response element-binding transcription factor 2 (MTF2) and similar proteins
  15. XM_036164858.1XP_036020751.1  metal-response element-binding transcription factor 2 isoform X2

    Conserved Domains (3) summary
    cd15578
    Location:254
    PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
    cd15580
    Location:101152
    PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
    pfam14061
    Location:442489
    Mtf2_C; Polycomb-like MTF2 factor 2
  16. XM_036164855.1XP_036020748.1  metal-response element-binding transcription factor 2 isoform X2

    Conserved Domains (3) summary
    cd15578
    Location:254
    PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
    cd15580
    Location:101152
    PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
    pfam14061
    Location:442489
    Mtf2_C; Polycomb-like MTF2 factor 2
  17. XM_011249416.4XP_011247718.1  metal-response element-binding transcription factor 2 isoform X2

    See identical proteins and their annotated locations for XP_011247718.1

    UniProtKB/Swiss-Prot
    Q02395
    Conserved Domains (3) summary
    cd15578
    Location:254
    PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
    cd15580
    Location:101152
    PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
    pfam14061
    Location:442489
    Mtf2_C; Polycomb-like MTF2 factor 2
  18. XM_036164866.1XP_036020759.1  metal-response element-binding transcription factor 2 isoform X2

    Conserved Domains (3) summary
    cd15578
    Location:254
    PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
    cd15580
    Location:101152
    PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
    pfam14061
    Location:442489
    Mtf2_C; Polycomb-like MTF2 factor 2

RNA

  1. XR_389261.5 RNA Sequence

  2. XR_004942441.1 RNA Sequence