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faah-1 Fatty acid amide hydrolase 1 [ Caenorhabditis elegans ]

Gene ID: 177613, updated on 23-Nov-2023

Summary

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Gene symbol
faah-1
Gene description
Fatty acid amide hydrolase 1
Primary source
WormBase:WBGene00015047
Locus tag
CELE_B0218.1
See related
AllianceGenome:WB:WBGene00015047
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable amidase activity and fatty acid amide hydrolase activity. Involved in positive regulation of axon regeneration. Is expressed in intestine and pharynx. Human ortholog(s) of this gene implicated in obesity and substance-related disorder. Orthologous to human FAAH (fatty acid amide hydrolase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: IV
Exon count:
6
Sequence:
Chromosome: IV; NC_003282.8 (8159387..8162010)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Protein kinase domain-containing protein Neighboring gene ncRNA Neighboring gene C-type lectin domain-containing protein Neighboring gene Ovule protein Neighboring gene C-type lectin domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of N-acyl phosphatidylethanolamine-specific phospholipase-D isoforms in the nematode Caenorhabditis elegans. Harrison N, et al. PLoS One, 2014. PMID 25423491, Free PMC Article
  2. Endocannabinoid-Goα signalling inhibits axon regeneration in Caenorhabditis elegans by antagonizing Gqα-PKC-JNK signalling. Pastuhov SI, et al. Nat Commun, 2012. PMID 23072806, Free PMC Article
  3. The conserved histone chaperone LIN-53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans. Müthel S, et al. Aging Cell, 2019 Dec. PMID 31397537, Free PMC Article
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables amidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fatty acid amide hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fatty acid amide hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in fatty acid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of axon regeneration IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
Fatty acid amide hydrolase 1
NP_501368.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    8159387..8162010
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_068967.8 → NP_501368.1  Fatty acid amide hydrolase 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501368.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    H2KY70, Q17449
    Conserved Domains (1) summary
    pfam01425
    Location:84 → 559
    Amidase; Amidase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q17449.1

Gene LinkOut

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