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pmk-2 Mitogen-activated protein kinase pmk-2;mitogen-activated protein kinase [ Caenorhabditis elegans ]

Gene ID: 177611, updated on 4-Jan-2025

Summary

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Official Symbol
pmk-2
Official Full Name
Mitogen-activated protein kinase pmk-2;mitogen-activated protein kinase
Primary source
WormBase:WBGene00004056
Locus tag
CELE_F42G8.3
See related
AllianceGenome:WB:WBGene00004056
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables MAP kinase activity. Involved in intracellular signal transduction and response to osmotic stress. Located in cytoplasm. Is expressed in ganglia; gonad; intestine; and somatic nervous system. Used to study cardiovascular system disease. Human ortholog(s) of this gene implicated in colon cancer; colorectal carcinoma; nasopharynx carcinoma; and rectum cancer. Orthologous to several human genes including MAPK11 (mitogen-activated protein kinase 11) and MAPK14 (mitogen-activated protein kinase 14). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See pmk-2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
10
Sequence:
Chromosome: IV; NC_003282.8 (8143500..8148648)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Interactor with SLO-1 Neighboring gene Mitogen-activated protein kinase pmk-3;Protein kinase domain-containing protein Neighboring gene Mitogen-activated protein kinase pmk-1 Neighboring gene Amidase domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Tissue expression pattern of PMK-2 p38 MAPK is established by the miR-58 family in C. elegans. Pagano DJ, et al. PLoS Genet, 2015 Feb. PMID 25671546, Free PMC Article
  2. Isolation and characterization of pmk-(1-3): three p38 homologs in Caenorhabditis elegans. Berman K, et al. Mol Cell Biol Res Commun, 2001 Nov. PMID 11703092, Free PMC Article
  3. A C. elegans MAP kinase pathway is required for wild-type display of an L1-specific surface antigen (srf-6 is nsy-1 III). Foley S, et al. MicroPubl Biol, 2019 Jul 4. PMID 32550420, Free PMC Article
  4. A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate immunity. Kim DH, et al. Science, 2002 Jul 26. PMID 12142542
  5. The C. elegans p38 MAPK pathway regulates nuclear localization of the transcription factor SKN-1 in oxidative stress response. Inoue H, et al. Genes Dev, 2005 Oct 1. PMID 16166371, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables MAP kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables MAP kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in response to osmotic stress IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Mitogen-activated protein kinase pmk-2;mitogen-activated protein kinase
NP_001368440.1
  • Confirmed by transcript evidence
NP_001368441.1
  • Confirmed by transcript evidence
NP_741457.2
  • Confirmed by transcript evidence
NP_741458.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    8143500..8148648
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_171392.7 → NP_741457.2  Mitogen-activated protein kinase pmk-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741457.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8MXI3, Q8MXI4
    Conserved Domains (1) summary
    cd07851
    Location:33 → 381
    STKc_p38; Catalytic domain of the Serine/Threonine Kinase, p38 Mitogen-Activated Protein Kinase

  2. NM_171913.6 → NP_741458.2  Mitogen-activated protein kinase pmk-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741458.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8MXI3, Q8MXI4
    Conserved Domains (2) summary
    cd07851
    Location:33 → 376
    STKc_p38; Catalytic domain of the Serine/Threonine Kinase, p38 Mitogen-Activated Protein Kinase
    smart00220
    Location:49 → 333
    S_TKc; Serine/Threonine protein kinases, catalytic domain

  3. NM_001380352.1 → NP_001368440.1  mitogen-activated protein kinase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    W6SBC9
    Conserved Domains (1) summary
    cl21453
    Location:1 → 178
    PKc_like; Protein Kinases, catalytic domain

  4. NM_001380353.1 → NP_001368441.1  mitogen-activated protein kinase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    W6RQY6
    Conserved Domains (1) summary
    cl21453
    Location:1 → 173
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
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