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rabs-5 FYVE-type domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 177603, updated on 2-Dec-2025
Official Symbol
rabs-5
Official Full Name
FYVE-type domain-containing protein
Primary source
WormBase:WBGene00021538
Locus tag
CELE_Y42H9AR.3
See related
AllianceGenome:WB:WBGene00021538
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable phosphatidylinositol-3-phosphate binding activity. Involved in pinocytosis and receptor-mediated endocytosis. Is expressed in PQR; amphid neurons; head; phasmid neurons; and ray neurons. Orthologous to human RBSN (rabenosyn, RAB effector). [provided by Alliance of Genome Resources, Jul 2025]
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See rabs-5 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
7
Sequence:
Chromosome: IV; NC_003282.8 (8104284..8107602, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Protein lifeguard 2 Neighboring gene FMRF-Like Peptide Neighboring gene ncRNA Neighboring gene ELM2 domain-containing protein Neighboring gene PDZ GRASP-type domain-containing protein

Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Endosome maturation factors Rabenosyn-5/VPS45 and caveolin-1 regulate ciliary membrane and polycystin-2 homeostasis. Scheidel N, et al. EMBO J, 2018 May 2. PMID 29572244, Free PMC Article
  2. The SM protein VPS-45 is required for RAB-5-dependent endocytic transport in Caenorhabditis elegans. Gengyo-Ando K, et al. EMBO Rep, 2007 Feb. PMID 17235359, Free PMC Article
  3. The WD40 and FYVE domain containing protein 2 defines a class of early endosomes necessary for endocytosis. Hayakawa A, et al. Proc Natl Acad Sci U S A, 2006 Aug 8. PMID 16873553, Free PMC Article
  4. DLK-1/p38 MAP Kinase Signaling Controls Cilium Length by Regulating RAB-5 Mediated Endocytosis in Caenorhabditis elegans. van der Vaart A, et al. PLoS Genet, 2015 Dec. PMID 26657059, Free PMC Article
  5. A pathway for phagosome maturation during engulfment of apoptotic cells. Kinchen JM, et al. Nat Cell Biol, 2008 May. PMID 18425118, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
FYVE-type domain-containing protein
NP_001294172.1
  • Confirmed by transcript evidence
NP_501352.1
  • Confirmed by transcript evidence

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    8104284..8107602 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_068951.4 → NP_501352.1  FYVE-type domain-containing protein

    See identical proteins and their annotated locations for NP_501352.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9N3Y4
    Conserved Domains (3) summary
    cl28890
    Location:173 → 218
    FYVE_like_SF; FYVE domain like superfamily
    pfam05605
    Location:21 → 47
    zf-Di19; Drought induced 19 protein (Di19), zinc-binding
    pfam11464
    Location:521 → 557
    Rbsn; Rabenosyn Rab binding domain

  2. NM_001307243.3 → NP_001294172.1  FYVE-type domain-containing protein

    See identical proteins and their annotated locations for NP_001294172.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    W6SBE5
    Conserved Domains (3) summary
    cl28890
    Location:173 → 218
    FYVE_like_SF; FYVE domain like superfamily
    pfam05605
    Location:21 → 47
    zf-Di19; Drought induced 19 protein (Di19), zinc-binding
    pfam11464
    Location:523 → 559
    Rbsn; Rabenosyn Rab binding domain
Nucleotide Protein
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