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sax-7 Fibronectin type-III domain-containing protein;Neuroglian [ Caenorhabditis elegans ]

Gene ID: 177602, updated on 3-Jun-2026
Official Symbol
sax-7
Official Full Name
Fibronectin type-III domain-containing protein;Neuroglian
Primary source
WormBase:WBGene00004732
Locus tag
CELE_C18F3.2
See related
AllianceGenome:WB:WBGene00004732
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables ankyrin binding activity. Involved in several processes, including gastrulation; neuron development; and regulation of cell morphogenesis. Located in several cellular components, including lateral plasma membrane; neuron projection membrane; and neuronal cell body membrane. Is expressed in several structures, including germ line; gonad; hypodermis; nervous system; and pharynx. Used to study MASA syndrome. Orthologous to human NFASC (neurofascin) and NRCAM (neuronal cell adhesion molecule). [provided by Alliance of Genome Resources, Jul 2025]
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See sax-7 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
19
Sequence:
Chromosome: IV; NC_003282.8 (8062659..8084087)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Transcription factor nsy-7 Neighboring gene ncRNA Neighboring gene Protein lifeguard 2

Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. LAD-1, the Caenorhabditis elegans L1CAM homologue, participates in embryonic and gonadal morphogenesis and is a substrate for fibroblast growth factor receptor pathway-dependent phosphotyrosine-based signaling. Chen L, et al. J Cell Biol, 2001 Aug 20. PMID 11502758, Free PMC Article
  2. Maintenance of neuronal positions in organized ganglia by SAX-7, a Caenorhabditis elegans homologue of L1. Sasakura H, et al. EMBO J, 2005 Apr 6. PMID 15775964, Free PMC Article
  3. Axon-dendrite and apical-basolateral sorting in a single neuron. Lillis M, et al. Genetics, 2022 May 5. PMID 35244146, Free PMC Article
  4. Functional dissection of the C. elegans cell adhesion molecule SAX-7, a homologue of human L1. Pocock R, et al. Mol Cell Neurosci, 2008 Jan. PMID 17933550
  5. The PVD neuron has male-specific structure and mating function in Caenorhabditis elegans. Iosilevskii Y, et al. Proc Natl Acad Sci U S A, 2025 Apr. PMID 40138342, Free PMC Article

See all (81) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Neuronal postdevelopmentally acting SAX-7S/L1CAM can function as cleaved fragments to maintain neuronal architecture in Caenorhabditis elegans.
    Title: Neuronal postdevelopmentally acting SAX-7S/L1CAM can function as cleaved fragments to maintain neuronal architecture in Caenorhabditis elegans.
  2. Harmonization of L1CAM expression facilitates axon outgrowth and guidance of a motor neuron.
    Title: Harmonization of L1CAM expression facilitates axon outgrowth and guidance of a motor neuron.
  3. dendrite development in C elegans requires the adhesion protein SAX-7/L1CAM and the cytoplasmic protein GRDN-1/CCDC88C to anchor dendrite endings at the nose
    Title: Dendrites with specialized glial attachments develop by retrograde extension using SAX-7 and GRDN-1.
  4. loss of the cell adhesion molecule (CAM) CDH-4/Fat-like cadherin causes dendrites to be ordered randomly, despite remaining bundled. Loss of the CAMs PTP-3/LAR or SAX-7/L1CAM causes dendrites to adopt an altered order, which becomes increasingly random as animals grow.
    Title: Ordered arrangement of dendrites within a C. elegans sensory nerve bundle.
  5. EFF-1 control dendrite morphology by regulating the localization pattern of SAX-7 in epidermal cells
    Title: Dynein and EFF-1 control dendrite morphology by regulating the localization pattern of SAX-7 in epidermal cells.
  6. The ligand complex SAX-7/L1CAM and MNR-1 function at defined locations in the surrounding hypodermal tissue, whereas DMA-1 acts as the cognate receptor on the sensory neuron PVD. Mutations in this complex lead to dramatic defects in the formation, stabilization, and organization of the dendritic arbor.
    Title: An extracellular adhesion molecule complex patterns dendritic branching and morphogenesis.
  7. These findings suggest an unexpected interdependency of distinct Ig domain proteins, with one isoform of SAX-7, SAX-7L, inhibiting the function of the most adhesive isoform, SAX-7S, and this inhibition being relieved by ZIG-5 and ZIG-8.
    Title: The secreted immunoglobulin domain proteins ZIG-5 and ZIG-8 cooperate with L1CAM/SAX-7 to maintain nervous system integrity.
  8. sax-7 and hmr-1 function redundantly in blastomere compaction and non-muscle myosin accumulation during C. elegans gastrulation.
    Title: SAX-7/L1CAM and HMR-1/cadherin function redundantly in blastomere compaction and non-muscle myosin accumulation during Caenorhabditis elegans gastrulation.
  9. the 6 Ig/5 FnIII domain protein SAX-7 acts autonomously in the nervous system to maintain axon position in the ventral nerve cord of the nematode.
    Title: Functional dissection of the C. elegans cell adhesion molecule SAX-7, a homologue of human L1.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
Fibronectin type-III domain-containing protein;Neuroglian
NP_001033394.1
  • Partially confirmed by transcript evidence
NP_001033395.1
  • Confirmed by transcript evidence
NP_001033396.1
  • Confirmed by transcript evidence
NP_001033397.1
  • Confirmed by transcript evidence
NP_001294161.1
  • Confirmed by transcript evidence
NP_001294162.1
  • Partially confirmed by transcript evidence

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    8062659..8084087
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001038307.5 → NP_001033396.1  Neuroglian

    See identical proteins and their annotated locations for NP_001033396.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q53U87
    Conserved Domains (7) summary
    smart00409
    Location:453 → 534
    IG; Immunoglobulin
    cd00063
    Location:755 → 857
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:64 → 128
    Ig; Immunoglobulin domain
    pfam00041
    Location:866 → 977
    fn3; Fibronectin type III domain
    pfam13882
    Location:1238 → 1310
    Bravo_FIGEY; Bravo-like intracellular region
    pfam13927
    Location:258 → 327
    Ig_3; Immunoglobulin domain
    cl11960
    Location:350 → 429
    Ig; Immunoglobulin domain

  2. NM_001038306.6 → NP_001033395.1  Neuroglian

    See identical proteins and their annotated locations for NP_001033395.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q4PIU9
    Conserved Domains (7) summary
    smart00409
    Location:453 → 534
    IG; Immunoglobulin
    cd00063
    Location:755 → 857
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:64 → 128
    Ig; Immunoglobulin domain
    pfam00041
    Location:866 → 977
    fn3; Fibronectin type III domain
    pfam13882
    Location:1238 → 1307
    Bravo_FIGEY; Bravo-like intracellular region
    pfam13927
    Location:258 → 327
    Ig_3; Immunoglobulin domain
    cl11960
    Location:350 → 429
    Ig; Immunoglobulin domain

  3. NM_001038305.3 → NP_001033394.1  Fibronectin type-III domain-containing protein

    See identical proteins and their annotated locations for NP_001033394.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q18100
    Conserved Domains (6) summary
    smart00409
    Location:269 → 350
    IG; Immunoglobulin
    cd00063
    Location:571 → 673
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:682 → 793
    fn3; Fibronectin type III domain
    pfam13882
    Location:1054 → 1123
    Bravo_FIGEY; Bravo-like intracellular region
    pfam13927
    Location:74 → 143
    Ig_3; Immunoglobulin domain
    cl11960
    Location:166 → 245
    Ig; Immunoglobulin domain

  4. NM_001038308.4 → NP_001033397.1  Fibronectin type-III domain-containing protein

    See identical proteins and their annotated locations for NP_001033397.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q53U86
    Conserved Domains (6) summary
    smart00410
    Location:269 → 350
    IG_like; Immunoglobulin like
    cd00063
    Location:571 → 673
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:682 → 793
    fn3; Fibronectin type III domain
    pfam13882
    Location:1054 → 1126
    Bravo_FIGEY; Bravo-like intracellular region
    pfam13927
    Location:74 → 143
    Ig_3; Immunoglobulin domain
    cl11960
    Location:166 → 245
    Ig; Immunoglobulin domain

  5. NM_001307233.3 → NP_001294162.1  Fibronectin type-III domain-containing protein

    See identical proteins and their annotated locations for NP_001294162.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    W6RTH3
    Conserved Domains (2) summary
    cd00063
    Location:25 → 102
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam13882
    Location:159 → 228
    Bravo_FIGEY; Bravo-like intracellular region

  6. NM_001307232.3 → NP_001294161.1  Fibronectin type-III domain-containing protein

    See identical proteins and their annotated locations for NP_001294161.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    W6RRX6
    Conserved Domains (2) summary
    cd00063
    Location:25 → 102
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam13882
    Location:159 → 231
    Bravo_FIGEY; Bravo-like intracellular region
Nucleotide Protein
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