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zgpa-1 Zinc finger CCCH-type with G patch domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 177568, updated on 7-Apr-2025

Summary

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Official Symbol
zgpa-1
Official Full Name
Zinc finger CCCH-type with G patch domain-containing protein
Primary source
WormBase:WBGene00016383
Locus tag
CELE_C33H5.17
See related
AllianceGenome:WB:WBGene00016383
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human ZGPAT (zinc finger CCCH-type and G-patch domain containing). [provided by Alliance of Genome Resources, Apr 2025]
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Genomic context

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See zgpa-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
4
Sequence:
Chromosome: IV; NC_003282.8 (7811146..7812809, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Glycosyltransferase family 92 protein C33H5.2 Neighboring gene ncRNA Neighboring gene Methyltransferase FkbM domain-containing protein Neighboring gene Phosphatidate cytidylyltransferase Neighboring gene ncRNA Neighboring gene Resistance to inhibitors of cholinesterase protein 3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Gene regulatory network inference in long-lived C. elegans reveals modular properties that are predictive of novel aging genes. Suriyalaksh M, et al. iScience, 2022 Jan 21. PMID 35036864, Free PMC Article
  2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Zinc finger CCCH-type with G patch domain-containing protein
NP_501296.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    7811146..7812809 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_068895.5 → NP_501296.1  Zinc finger CCCH-type with G patch domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501296.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q18418
    Conserved Domains (3) summary
    smart00356
    Location:121 → 144
    ZnF_C3H1; zinc finger
    pfam01585
    Location:249 → 289
    G-patch; G-patch domain
    cl17182
    Location:254 → 421
    NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate
Nucleotide Protein
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