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itr-1 Inositol 1,4,5-trisphosphate receptor itr-1 [ Caenorhabditis elegans ]

Gene ID: 177546, updated on 10-Oct-2019

Summary

Gene symbol
itr-1
Gene description
Inositol 1,4,5-trisphosphate receptor itr-1
Primary source
WormBase:WBGene00002173
Locus tag
CELE_F33D4.2
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis

Genomic context

See itr-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
38
Sequence:
Chromosome: IV; NC_003282.8 (7675174..7696930)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene SPSAVPLIRF-amide Neighboring gene ncRNA Neighboring gene Putative sphingolipid delta(4)-desaturase

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
calcium channel activity IEA
Inferred from Electronic Annotation
more info
 
calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inositol 1,4,5 trisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inositol 1,4,5 trisphosphate binding IEA
Inferred from Electronic Annotation
more info
 
inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity IEA
Inferred from Electronic Annotation
more info
 
inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
ion channel activity IEA
Inferred from Electronic Annotation
more info
 
myosin binding IPI
Inferred from Physical Interaction
more info
PubMed 
phosphatidylinositol binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
calcium ion transport IEA
Inferred from Electronic Annotation
more info
 
defecation IGI
Inferred from Genetic Interaction
more info
PubMed 
defecation IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
hermaphrodite genitalia morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
inositol lipid-mediated signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
inositol phosphate-mediated signaling IEA
Inferred from Electronic Annotation
more info
 
ion transport IEA
Inferred from Electronic Annotation
more info
 
male mating behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
multicellular organismal reproductive process IGI
Inferred from Genetic Interaction
more info
PubMed 
muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
oocyte maturation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of cytosolic calcium ion concentration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of pharyngeal pumping IPI
Inferred from Physical Interaction
more info
PubMed 
programmed cell death IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of filopodium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of pharyngeal pumping IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of pharyngeal pumping IMP
Inferred from Mutant Phenotype
more info
PubMed 
release of sequestered calcium ion into cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
rhythmic behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
sperm ejaculation IMP
Inferred from Mutant Phenotype
more info
PubMed 
transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasmic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sarcoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
secretory granule membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
Inositol 1,4,5-trisphosphate receptor itr-1
NP_001023170.1
  • Confirmed by transcript evidence
NP_001023171.1
  • Confirmed by transcript evidence
NP_001023172.1
  • Confirmed by transcript evidence
NP_001023173.1
  • Partially confirmed by transcript evidence
NP_001023174.1
  • Partially confirmed by transcript evidence
NP_001255305.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    7675174..7696930
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001027999.4NP_001023170.1  Inositol 1,4,5-trisphosphate receptor itr-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023170.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9Y0A1
    Conserved Domains (8) summary
    TIGR04370
    Location:24522640
    glyco_rpt_poly; oligosaccharide repeat unit polymerase
    pfam00520
    Location:25702764
    Ion_trans; Ion transport protein
    pfam01365
    Location:593787
    RYDR_ITPR; RIH domain
    pfam02815
    Location:320548
    MIR; MIR domain
    pfam06432
    Location:24472539
    GPI2; Phosphatidylinositol N-acetylglucosaminyltransferase
    pfam08454
    Location:20732176
    RIH_assoc; RyR and IP3R Homology associated
    pfam08709
    Location:78312
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
    cl01736
    Location:25072636
    PelG; Putative exopolysaccharide Exporter (EPS-E)
  2. NM_001028000.4NP_001023171.1  Inositol 1,4,5-trisphosphate receptor itr-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023171.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9Y0A1
    Conserved Domains (8) summary
    TIGR04370
    Location:23962584
    glyco_rpt_poly; oligosaccharide repeat unit polymerase
    pfam00520
    Location:25142708
    Ion_trans; Ion transport protein
    pfam01365
    Location:537731
    RYDR_ITPR; RIH domain
    pfam02815
    Location:264492
    MIR; MIR domain
    pfam06432
    Location:23912483
    GPI2; Phosphatidylinositol N-acetylglucosaminyltransferase
    pfam08454
    Location:20172120
    RIH_assoc; RyR and IP3R Homology associated
    pfam08709
    Location:22256
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
    cl01736
    Location:24512580
    PelG; Putative exopolysaccharide Exporter (EPS-E)
  3. NM_001028002.3NP_001023173.1  Inositol 1,4,5-trisphosphate receptor itr-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023173.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9Y0A1
    Conserved Domains (8) summary
    TIGR04370
    Location:24062594
    glyco_rpt_poly; oligosaccharide repeat unit polymerase
    pfam00520
    Location:25242718
    Ion_trans; Ion transport protein
    pfam01365
    Location:547741
    RYDR_ITPR; RIH domain
    pfam02815
    Location:274502
    MIR; MIR domain
    pfam06432
    Location:24012493
    GPI2; Phosphatidylinositol N-acetylglucosaminyltransferase
    pfam08454
    Location:20272130
    RIH_assoc; RyR and IP3R Homology associated
    pfam08709
    Location:32266
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
    cl01736
    Location:24612590
    PelG; Putative exopolysaccharide Exporter (EPS-E)
  4. NM_001268376.2NP_001255305.1  Inositol 1,4,5-trisphosphate receptor itr-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255305.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9Y0A1
    Conserved Domains (8) summary
    TIGR04370
    Location:24272615
    glyco_rpt_poly; oligosaccharide repeat unit polymerase
    pfam00520
    Location:25452739
    Ion_trans; Ion transport protein
    pfam01365
    Location:547741
    RYDR_ITPR; RIH domain
    pfam02815
    Location:274502
    MIR; MIR domain
    pfam06432
    Location:24222514
    GPI2; Phosphatidylinositol N-acetylglucosaminyltransferase
    pfam08454
    Location:20482151
    RIH_assoc; RyR and IP3R Homology associated
    pfam08709
    Location:32266
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
    cl01736
    Location:24822611
    PelG; Putative exopolysaccharide Exporter (EPS-E)
  5. NM_001028003.3NP_001023174.1  Inositol 1,4,5-trisphosphate receptor itr-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023174.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9Y0A1
    Conserved Domains (3) summary
    pfam01365
    Location:547741
    RYDR_ITPR; RIH domain
    pfam02815
    Location:274502
    MIR; MIR domain
    pfam08709
    Location:32266
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
  6. NM_001028001.3NP_001023172.1  Inositol 1,4,5-trisphosphate receptor itr-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023172.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9Y0A1
    Conserved Domains (8) summary
    TIGR04370
    Location:24172605
    glyco_rpt_poly; oligosaccharide repeat unit polymerase
    pfam00520
    Location:25352729
    Ion_trans; Ion transport protein
    pfam01365
    Location:556750
    RYDR_ITPR; RIH domain
    pfam02815
    Location:274511
    MIR; MIR domain
    pfam06432
    Location:24122504
    GPI2; Phosphatidylinositol N-acetylglucosaminyltransferase
    pfam08454
    Location:20382141
    RIH_assoc; RyR and IP3R Homology associated
    pfam08709
    Location:32266
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
    cl01736
    Location:24722601
    PelG; Putative exopolysaccharide Exporter (EPS-E)
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