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R05G6.10 Ras-GEF domain-containing family member 1B;Ras-GEF domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 177527, updated on 11-Apr-2024

Summary

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Gene symbol
R05G6.10
Gene description
Ras-GEF domain-containing family member 1B;Ras-GEF domain-containing protein
Primary source
WormBase:WBGene00019902
Locus tag
CELE_R05G6.10
See related
AllianceGenome:WB:WBGene00019902
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of catalytic activity and small GTPase mediated signal transduction. Is expressed in intestine; neurons; pharynx; and rectal gland cell. Orthologous to several human genes including RASGEF1B (RasGEF domain family member 1B). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See R05G6.10 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
12
Sequence:
Chromosome: IV; NC_003282.8 (7517445..7542535, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene EGF-like domain-containing protein Neighboring gene Venom peptide Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Phospholipid scramblase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Puromycin-sensitive aminopeptidase Neighboring gene Cytidine deaminase Neighboring gene C2H2-type domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
  2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Ras-GEF domain-containing family member 1B;Ras-GEF domain-containing protein
NP_001294201.1
  • Partially confirmed by transcript evidence
NP_001294202.1
  • Partially confirmed by transcript evidence
NP_001294203.1
  • Partially confirmed by transcript evidence
NP_001368452.1
  • Confirmed by transcript evidence
NP_501217.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    7517445..7542535 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_068816.7 → NP_501217.2  Ras-GEF domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501217.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q21758
    Conserved Domains (2) summary
    smart00147
    Location:193 → 446
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:30 → 156
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

  2. NM_001307272.4 → NP_001294201.1  Ras-GEF domain-containing family member 1B [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294201.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    W6RS10
    Conserved Domains (2) summary
    smart00147
    Location:279 → 532
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:116 → 242
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

  3. NM_001307273.3 → NP_001294202.1  Ras-GEF domain-containing family member 1B [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294202.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    W6RTN2
    Conserved Domains (2) summary
    smart00147
    Location:264 → 517
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:101 → 227
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

  4. NM_001307274.3 → NP_001294203.1  Ras-GEF domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294203.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    W6SBJ9
    Conserved Domains (2) summary
    smart00147
    Location:221 → 474
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:58 → 184
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

  5. NM_001380329.1 → NP_001368452.1  Ras-GEF domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    W6RY82
    Conserved Domains (2) summary
    smart00147
    Location:110 → 363
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cl02520
    Location:8 → 73
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
Nucleotide Protein
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