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Mt1 metallothionein 1 [ Mus musculus (house mouse) ]

Gene ID: 17748, updated on 5-Jan-2023

Summary

Official Symbol
Mt1provided by MGI
Official Full Name
metallothionein 1provided by MGI
Primary source
MGI:MGI:97171
See related
Ensembl:ENSMUSG00000031765 AllianceGenome:MGI:97171
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MT-I; Mt-1
Summary
Enables copper ion binding activity. Involved in negative regulation of neuron apoptotic process. Acts upstream of or within several processes, including cellular response to chromate; cellular response to zinc ion; and cellular zinc ion homeostasis. Located in cytosol and lysosome. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; liver; and nasal cavity epithelium. Orthologous to several human genes including MT1A (metallothionein 1A); MT1E (metallothionein 1E); and MT1F (metallothionein 1F). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14.5 (RPKM 1065.3), stomach adult (RPKM 765.6) and 21 other tissues See more
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Genomic context

See Mt1 in Genome Data Viewer
Location:
8 C5; 8 46.34 cM
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (94905214..94906955)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (94178883..94180327)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39227 Neighboring gene uncharacterized LOC118567560 Neighboring gene metallothionein 2 Neighboring gene ribosomal protein L10, pseudogene 5 Neighboring gene nucleoporin 93

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables copper ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in lysosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
metallothionein-1
Names
metallothionein-I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013602.3NP_038630.1  metallothionein-1

    See identical proteins and their annotated locations for NP_038630.1

    Status: VALIDATED

    Source sequence(s)
    AA050166, AC131733, AK018727
    Consensus CDS
    CCDS40438.1
    UniProtKB/Swiss-Prot
    P02802, Q64485
    UniProtKB/TrEMBL
    A0A8C6GA99
    Related
    ENSMUSP00000034215.7, ENSMUST00000034215.8
    Conserved Domains (1) summary
    pfam00131
    Location:461
    Metallothio; Metallothionein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    94905214..94906955
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530752.5XP_006530815.1  metallothionein-1 isoform X1

    See identical proteins and their annotated locations for XP_006530815.1

    UniProtKB/TrEMBL
    A0A1D5RLN7
    Related
    ENSMUSP00000148443.2, ENSMUST00000212291.2
    Conserved Domains (1) summary
    cl19543
    Location:132
    Metallothio; Metallothionein