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swsn-6 SWI/SNF nucleosome remodeling complex component [ Caenorhabditis elegans ]

Gene ID: 177325, updated on 5-Jun-2022

Summary

Gene symbol
swsn-6
Gene description
SWI/SNF nucleosome remodeling complex component
Primary source
WormBase:WBGene00022774
Locus tag
CELE_ZK616.4
See related
AllianceGenome:WB:WBGene00022774
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable chromatin binding activity. Predicted to be involved in histone H4 acetylation; nervous system development; and regulation of transcription by RNA polymerase II. Predicted to be part of NuA4 histone acetyltransferase complex and SWI/SNF complex. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 76. Orthologous to several human genes including ACTL6B (actin like 6B). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See swsn-6 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
8
Sequence:
Chromosome: IV; NC_003282.8 (5395033..5396969)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene ER membrane protein complex subunit 4 Neighboring gene ncRNA Neighboring gene CHCH domain-containing protein Neighboring gene Uncharacterized protein

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the swsn-6 gene: The swsn-6 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, A.thaliana, rice, and frog.
  • Orthologs

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in histone H4 acetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of NuA4 histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of SWI/SNF complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
SWI/SNF nucleosome remodeling complex component
NP_500801.2
  • Product from WormBase gene class swsn;
    Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    5395033..5396969
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_068400.7NP_500801.2  SWI/SNF nucleosome remodeling complex component [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_500801.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9N4N4
    Conserved Domains (2) summary
    pfam00022
    Location:11436
    Actin; Actin
    cl17037
    Location:10435
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily