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mt-Nd4l NADH dehydrogenase 4L, mitochondrial [ Mus musculus (house mouse) ]

Gene ID: 17720, updated on 5-Jul-2025
Official Symbol
mt-Nd4lprovided by MGI
Official Full Name
NADH dehydrogenase 4L, mitochondrialprovided by MGI
Primary source
MGI:MGI:102497
See related
AllianceGenome:MGI:102497
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus (strain: C57BL/6J)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ND4L
Summary
Predicted to enable NADH dehydrogenase (ubiquinone) activity. Predicted to be involved in proton motive force-driven mitochondrial ATP synthesis. Located in mitochondrion. Part of respiratory chain complex I. Is active in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in Leber hereditary optic neuropathy and diabetes mellitus. Orthologous to human MT-ND4L (mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4L). [provided by Alliance of Genome Resources, Jul 2025]
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See mt-Nd4l in Genome Data Viewer
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) MT (non-nuclear) NC_005089.1 (9877..10173)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) MT (non-nuclear) NC_005089.1 (9877..10173)

Chromosome MT - NC_005089.1Genomic Context describing neighboring genes Neighboring gene NADH dehydrogenase subunit 3 Neighboring gene tRNA-Arg Neighboring gene NADH dehydrogenase subunit 4 Neighboring gene tRNA-His Neighboring gene tRNA-Ser Neighboring gene tRNA-Leu

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

  • URF4L

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NADH dehydrogenase (ubiquinone) activity IEA
Inferred from Electronic Annotation
more info
 
enables NADH dehydrogenase (ubiquinone) activity ISO
Inferred from Sequence Orthology
more info
 
enables oxidoreductase activity, acting on NAD(P)H IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in ATP synthesis coupled electron transport IEA
Inferred from Electronic Annotation
more info
 
involved_in aerobic respiration NAS
Non-traceable Author Statement
more info
PubMed 
involved_in proton motive force-driven mitochondrial ATP synthesis NAS
Non-traceable Author Statement
more info
PubMed 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
part_of respiratory chain complex I IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of respiratory chain complex I IDA
Inferred from Direct Assay
more info
PubMed 
part_of respiratory chain complex I IEA
Inferred from Electronic Annotation
more info
 
part_of respiratory chain complex I ISO
Inferred from Sequence Orthology
more info
 
Names
NADH dehydrogenase subunit 4L
NP_904336.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_005089.1 Reference assembly

    Range
    9877..10173
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_904336.1 NADH dehydrogenase subunit 4L (mitochondrion) [Mus musculus]

    See identical proteins and their annotated locations for NP_904336.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P03903
    UniProtKB/TrEMBL
    A0A0C4G448, Q7JD00, Q7YBV2, Q9MD77
    Related
    ENSMUSP00000081021.1
    Conserved Domains (1) summary
    MTH00107
    Location:198
    ND4L; NADH dehydrogenase subunit 4L; Provisional