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mt-Nd3 NADH dehydrogenase 3, mitochondrial [ Mus musculus (house mouse) ]

Gene ID: 17718, updated on 8-Dec-2022

Summary

Official Symbol
mt-Nd3provided by MGI
Official Full Name
NADH dehydrogenase 3, mitochondrialprovided by MGI
Primary source
MGI:MGI:102499
See related
AllianceGenome:MGI:102499
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus (strain: C57BL/6J)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ND3
Summary
Predicted to enable NADH dehydrogenase (ubiquinone) activity. Predicted to be involved in cellular response to glucocorticoid stimulus; mitochondrial electron transport, NADH to ubiquinone; and response to oxidative stress. Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Human ortholog(s) of this gene implicated in Leber hereditary optic neuropathy; Leigh disease; and Parkinson's disease. Orthologous to human MT-ND3 (mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See mt-Nd3 in Genome Data Viewer
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) MT (non-nuclear) NC_005089.1 (9459..9806)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) MT (non-nuclear) NC_005089.1 (9459..9806)

Chromosome MT - NC_005089.1Genomic Context describing neighboring genes Neighboring gene ATP synthase F0 subunit 6 Neighboring gene cytochrome c oxidase subunit III Neighboring gene tRNA-Gly Neighboring gene tRNA-Arg Neighboring gene NADH dehydrogenase subunit 4L Neighboring gene NADH dehydrogenase subunit 4

Genomic regions, transcripts, and products

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

variation

  • Loc: 9461 replace = c

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NADH dehydrogenase (ubiquinone) activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables NADH dehydrogenase (ubiquinone) activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of NADH dehydrogenase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
part_of mitochondrial respiratory chain complex I ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
located_in respirasome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Names
NADH dehydrogenase subunit 3
NP_904335.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_005089.1 Reference assembly

    Range
    9459..9806
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_904335.1 NADH dehydrogenase subunit 3 (mitochondrion) [Mus musculus]

    See identical proteins and their annotated locations for NP_904335.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P03899, Q9MD73
    UniProtKB/TrEMBL
    A3R485, Q7GIP5
    Related
    ENSMUSP00000080998.1
    Conserved Domains (1) summary
    MTH00106
    Location:1115
    ND3; NADH dehydrogenase subunit 3; Provisional