Msl3 MSL complex subunit 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Msl3provided by MGI
Official Full Name: MSL complex subunit 3provided by MGI
Primary source: MGI:MGI:1341851
See related: Ensembl:ENSMUSG00000031358 AllianceGenome:MGI:1341851
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Msl31; Msl3l1
Summary: Predicted to enable DNA binding activity; histone acetyltransferase activity (H4-K16 specific); and methylated histone binding activity. Predicted to be involved in heterochromatin assembly and histone modification. Predicted to act upstream of or within chromatin organization. Predicted to be located in nucleus. Predicted to be part of MSL complex and NuA4 histone acetyltransferase complex. Is expressed in embryo; limb; and limb mesenchyme. Human ortholog(s) of this gene implicated in Basilicata-Akhtar syndrome. Orthologous to human MSL3 (MSL complex subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in bladder adult (RPKM 7.1), placenta adult (RPKM 6.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: X; X F5

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (167434263..167457347, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (168651267..168674354, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that complete removal of paternally expressed gene 3 (PEG3) resulted in up-regulation of male-specific lethal 1 (Msl1) and male-specific lethal 3 (Msl3).
Title: PEG3 control on the mammalian MSL complex.
Msl1 interacts with Msl3 as an extended chain forming an extensive hydrophobic interface, whereas the Msl1-MOF interface involves electrostatic interactions between the HAT domain and a long helix of Msl1.
Title: Structural basis for MOF and MSL3 recruitment into the dosage compensation complex by MSL1.
Analysis of Mid1, Hccs, Arhgap6, and Msl3l1 in X-linked polydactyly (Xpl) and Patchy-fur (Paf) mutant mice
Title: Analysis of Mid1, Hccs, Arhgap6, and Msl3l1 in X-linked polydactyly (Xpl) and Patchy-fur (Paf) mutant mice.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH136518 (e-PCR)
- UniSTS:210500

AW556142 (e-PCR)
- UniSTS:209551

Homology

Homologs of the Msl3 gene: The Msl3 gene is conserved in human, chimpanzee, dog, cow, rat, chicken, fruit fly, mosquito, and frog.
Orthologs from Annotation Pipeline: 339 organisms have orthologs with human gene Msl3
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables histone H4K16 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables methylated histone binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in histone H2A acetylation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in histone H4-K16 acetylation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in histone H4-K16 acetylation	ISO Inferred from Sequence Orthology more info
involved_in histone deacetylation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of dosage compensation by inactivation of X chromosome	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of MSL complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of MSL complex	ISO Inferred from Sequence Orthology more info
part_of NuA4 histone acetyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: male-specific lethal 3 homolog

Names: male-specific lethal-3 homolog 1; male-specific lethal-3 protein-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001370791.1 → NP_001357720.1 male-specific lethal 3 homolog isoform 1

Status: VALIDATED

Source sequence(s)

AL671489

Consensus CDS

CCDS90775.1

UniProtKB/Swiss-Prot

B1AUJ8

UniProtKB/TrEMBL

A0A6P5P5G4

Related

ENSMUSP00000033725.10, ENSMUST00000033725.16

Conserved Domains (3) summary

cd18983
Location:15 → 81

CBD_MSL3_like; chromo barrel domain of human male-specific lethal complex subunit 3, and similar proteins

pfam05712
Location:176 → 510

MRG

pfam12258
Location:313 → 412

Microcephalin; Microcephalin protein
NM_001370792.1 → NP_001357721.1 male-specific lethal 3 homolog isoform 2

Status: VALIDATED

Source sequence(s)

AL671489

UniProtKB/TrEMBL

A0A6P5NZT1

Conserved Domains (3) summary

cd18983
Location:15 → 81

CBD_MSL3_like; chromo barrel domain of human male-specific lethal complex subunit 3, and similar proteins

pfam05712
Location:175 → 509

MRG

pfam12258
Location:312 → 411

Microcephalin; Microcephalin protein
NM_001370793.1 → NP_001357722.1 male-specific lethal 3 homolog isoform 3

Status: VALIDATED

Source sequence(s)

AL671489

Conserved Domains (3) summary

pfam05712
Location:154 → 488

MRG

pfam12258
Location:291 → 390

Microcephalin; Microcephalin protein

cl28914
Location:12 → 59

CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains
NM_001370794.1 → NP_001357723.1 male-specific lethal 3 homolog isoform 4

Status: VALIDATED

Source sequence(s)

AL671489

Conserved Domains (3) summary

cd18983
Location:15 → 81

CBD_MSL3_like; chromo barrel domain of human male-specific lethal complex subunit 3, and similar proteins

pfam05712
Location:175 → 499

MRG

pfam12258
Location:312 → 411

Microcephalin; Microcephalin protein
NM_001370795.1 → NP_001357724.1 male-specific lethal 3 homolog isoform 6

Status: VALIDATED

Source sequence(s)

AL671489

UniProtKB/TrEMBL

A0A6P7QRG7

Conserved Domains (3) summary

pfam05712
Location:116 → 450

MRG

pfam12258
Location:253 → 352

Microcephalin; Microcephalin protein

cl28914
Location:3 → 22

CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains
NM_001370796.1 → NP_001357725.1 male-specific lethal 3 homolog isoform 7

Status: VALIDATED

Source sequence(s)

AL671489

Conserved Domains (3) summary

pfam05712
Location:117 → 441

MRG

pfam12258
Location:254 → 353

Microcephalin; Microcephalin protein

cl28914
Location:3 → 22

CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains
NM_001370797.1 → NP_001357726.1 male-specific lethal 3 homolog isoform 8

Status: VALIDATED

Source sequence(s)

AL671489

Conserved Domains (3) summary

pfam05712
Location:116 → 440

MRG

pfam12258
Location:253 → 352

Microcephalin; Microcephalin protein

cl28914
Location:3 → 22

CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains
NM_001370798.1 → NP_001357727.1 male-specific lethal 3 homolog isoform 9

Status: VALIDATED

Source sequence(s)

AL671489

Conserved Domains (3) summary

pfam05712
Location:120 → 426

MRG

pfam12258
Location:229 → 328

Microcephalin; Microcephalin protein

cl28914
Location:3 → 22

CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains
NM_001370799.1 → NP_001357728.1 male-specific lethal 3 homolog isoform 10

Status: VALIDATED

Source sequence(s)

AL671489

Conserved Domains (3) summary

pfam05712
Location:117 → 241

MRG

pfam12258
Location:254 → 353

Microcephalin; Microcephalin protein

cl28914
Location:3 → 22

CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains
NM_001411770.1 → NP_001398699.1 male-specific lethal 3 homolog isoform 11

Status: VALIDATED

Source sequence(s)

AL671489
NM_001411771.1 → NP_001398700.1 male-specific lethal 3 homolog isoform 12

Status: VALIDATED

Source sequence(s)

AL671489
NM_001411772.1 → NP_001398701.1 male-specific lethal 3 homolog isoform 13

Status: VALIDATED

Source sequence(s)

AL671489
NM_010832.6 → NP_034962.2 male-specific lethal 3 homolog isoform 5

See identical proteins and their annotated locations for NP_034962.2

Status: VALIDATED

Source sequence(s)

AL671489

Consensus CDS

CCDS41211.1

UniProtKB/Swiss-Prot

Q9WVG9

UniProtKB/TrEMBL

A0A6P5P939

Related

ENSMUSP00000107765.2, ENSMUST00000112137.2

Conserved Domains (3) summary

pfam05712
Location:117 → 451

MRG

pfam12258
Location:254 → 353

Microcephalin; Microcephalin protein

cl28914
Location:3 → 22

CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000086.8 Reference GRCm39 C57BL/6J

Range

167434263..167457347 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017318415.3 → XP_017173904.1 male-specific lethal 3 homolog isoform X1

Conserved Domains (3) summary

cd18983
Location:15 → 81

CBD_MSL3_like; chromo barrel domain of human male-specific lethal complex subunit 3, and similar proteins

pfam05712
Location:176 → 500

MRG

pfam12258
Location:313 → 412

Microcephalin; Microcephalin protein
XM_036161839.1 → XP_036017732.1 male-specific lethal 3 homolog isoform X4

Conserved Domains (1) summary

pfam05712
Location:5 → 340

MRG
XM_036161838.1 → XP_036017731.1 male-specific lethal 3 homolog isoform X3

Conserved Domains (2) summary

pfam05712
Location:144 → 478

MRG

cl28914
Location:12 → 59

CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains
XM_036161837.1 → XP_036017730.1 male-specific lethal 3 homolog isoform X2

Conserved Domains (2) summary

pfam05712
Location:143 → 487

MRG

cl28914
Location:12 → 59

CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains