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Msl3 MSL complex subunit 3 [ Mus musculus (house mouse) ]

Gene ID: 17692, updated on 7-Apr-2025

Summary

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Official Symbol
Msl3provided by MGI
Official Full Name
MSL complex subunit 3provided by MGI
Primary source
MGI:MGI:1341851
See related
Ensembl:ENSMUSG00000031358 AllianceGenome:MGI:1341851
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Msl31; Msl3l1
Summary
Predicted to enable DNA binding activity; histone reader activity; and methylated histone binding activity. Involved in positive regulation of DNA-templated transcription. Part of MSL complex. Is expressed in cerebral cortex ventricular layer; embryo; limb; and limb mesenchyme. Human ortholog(s) of this gene implicated in Basilicata-Akhtar syndrome. Orthologous to human MSL3 (MSL complex subunit 3). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Ubiquitous expression in bladder adult (RPKM 7.1), placenta adult (RPKM 6.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Msl3 in Genome Data Viewer
Location:
X F5; X 78.73 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (167434263..167456868, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (168651267..168674354, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene FERM and PDZ domain containing 4 Neighboring gene STARR-seq mESC enhancer starr_48277 Neighboring gene predicted pseudogene 7209 Neighboring gene STARR-positive B cell enhancer mm9_chrX:165110350-165110651 Neighboring gene STARR-seq mESC enhancer starr_48278 Neighboring gene predicted gene, 39550 Neighboring gene STARR-seq mESC enhancer starr_48279 Neighboring gene Rho GTPase activating protein 6 Neighboring gene STARR-seq mESC enhancer starr_48280 Neighboring gene STARR-positive B cell enhancer mm9_chrX:165523946-165524246 Neighboring gene STARR-seq mESC enhancer starr_48281 Neighboring gene amelogenin, X-linked Neighboring gene holocytochrome c synthetase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Loss of function of male-specific lethal 3 (Msl3) does not affect spermatogenesis in rodents. Mitchell TA, et al. Dev Dyn, 2024 May. PMID 37847071,
  2. Characterization of a novel chromo domain gene in xp22.3 with homology to Drosophila msl-3. Prakash SK, et al. Genomics, 1999 Jul 1. PMID 10395802
  3. Analysis of Mid1, Hccs, Arhgap6, and Msl3l1 in X-linked polydactyly (Xpl) and Patchy-fur (Paf) mutant mice. Cormier TA, et al. Mamm Genome, 2001 Oct. PMID 11668396
  4. Sexual differentiation in the developing mouse brain: contributions of sex chromosome genes. Wolstenholme JT, et al. Genes Brain Behav, 2013 Mar. PMID 23210685, Free PMC Article
  5. Structural basis for MOF and MSL3 recruitment into the dosage compensation complex by MSL1. Kadlec J, et al. Nat Struct Mol Biol, 2011 Feb. PMID 21217699

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss of function of male-specific lethal 3 (Msl3) does not affect spermatogenesis in rodents.
    Title: Loss of function of male-specific lethal 3 (Msl3) does not affect spermatogenesis in rodents.
  2. Data show that complete removal of paternally expressed gene 3 (PEG3) resulted in up-regulation of male-specific lethal 1 (Msl1) and male-specific lethal 3 (Msl3).
    Title: PEG3 control on the mammalian MSL complex.
  3. Msl1 interacts with Msl3 as an extended chain forming an extensive hydrophobic interface, whereas the Msl1-MOF interface involves electrostatic interactions between the HAT domain and a long helix of Msl1.
    Title: Structural basis for MOF and MSL3 recruitment into the dosage compensation complex by MSL1.
  4. Analysis of Mid1, Hccs, Arhgap6, and Msl3l1 in X-linked polydactyly (Xpl) and Patchy-fur (Paf) mutant mice
    Title: Analysis of Mid1, Hccs, Arhgap6, and Msl3l1 in X-linked polydactyly (Xpl) and Patchy-fur (Paf) mutant mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables histone reader activity ISO
Inferred from Sequence Orthology
more info
  
enables methylated histone binding ISO
Inferred from Sequence Orthology
more info
  
enables methylated histone binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of MSL complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of MSL complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of MSL complex ISO
Inferred from Sequence Orthology
more info
  
part_of MSL complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of NuA4 histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
MSL complex subunit 3; male-specific lethal 3 homolog
Names
male-specific lethal-3 homolog 1
male-specific lethal-3 protein-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001370791.1 → NP_001357720.1  MSL complex subunit 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL671489
    Consensus CDS
    CCDS90775.1
    UniProtKB/Swiss-Prot
    B1AUJ7, B1AUJ8, Q9WVG9
    Related
    ENSMUSP00000033725.10, ENSMUST00000033725.16
    Conserved Domains (3) summary
    cd18983
    Location:15 → 81
    CBD_MSL3_like; chromo barrel domain of human male-specific lethal complex subunit 3, and similar proteins
    pfam05712
    Location:176 → 510
    MRG
    pfam12258
    Location:313 → 412
    Microcephalin; Microcephalin protein

  2. NM_001370792.1 → NP_001357721.1  MSL complex subunit 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL671489
    Conserved Domains (3) summary
    cd18983
    Location:15 → 81
    CBD_MSL3_like; chromo barrel domain of human male-specific lethal complex subunit 3, and similar proteins
    pfam05712
    Location:175 → 509
    MRG
    pfam12258
    Location:312 → 411
    Microcephalin; Microcephalin protein

  3. NM_001370793.1 → NP_001357722.1  MSL complex subunit 3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL671489
    Conserved Domains (3) summary
    pfam05712
    Location:154 → 488
    MRG
    pfam12258
    Location:291 → 390
    Microcephalin; Microcephalin protein
    cl28914
    Location:12 → 59
    CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains

  4. NM_001370794.1 → NP_001357723.1  MSL complex subunit 3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL671489
    Conserved Domains (3) summary
    cd18983
    Location:15 → 81
    CBD_MSL3_like; chromo barrel domain of human male-specific lethal complex subunit 3, and similar proteins
    pfam05712
    Location:175 → 499
    MRG
    pfam12258
    Location:312 → 411
    Microcephalin; Microcephalin protein

  5. NM_001370795.1 → NP_001357724.1  MSL complex subunit 3 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL671489
    Conserved Domains (3) summary
    pfam05712
    Location:116 → 450
    MRG
    pfam12258
    Location:253 → 352
    Microcephalin; Microcephalin protein
    cl28914
    Location:3 → 22
    CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains

  6. NM_001370796.1 → NP_001357725.1  MSL complex subunit 3 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL671489
    Conserved Domains (3) summary
    pfam05712
    Location:117 → 441
    MRG
    pfam12258
    Location:254 → 353
    Microcephalin; Microcephalin protein
    cl28914
    Location:3 → 22
    CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains

  7. NM_001370797.1 → NP_001357726.1  MSL complex subunit 3 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL671489
    Conserved Domains (3) summary
    pfam05712
    Location:116 → 440
    MRG
    pfam12258
    Location:253 → 352
    Microcephalin; Microcephalin protein
    cl28914
    Location:3 → 22
    CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains

  8. NM_001370798.1 → NP_001357727.1  MSL complex subunit 3 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AL671489
    Conserved Domains (3) summary
    pfam05712
    Location:120 → 426
    MRG
    pfam12258
    Location:229 → 328
    Microcephalin; Microcephalin protein
    cl28914
    Location:3 → 22
    CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains

  9. NM_001370799.1 → NP_001357728.1  MSL complex subunit 3 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AL671489
    Conserved Domains (3) summary
    pfam05712
    Location:117 → 241
    MRG
    pfam12258
    Location:254 → 353
    Microcephalin; Microcephalin protein
    cl28914
    Location:3 → 22
    CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains

  10. NM_001411770.1 → NP_001398699.1  MSL complex subunit 3 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AL671489

  11. NM_001411771.1 → NP_001398700.1  MSL complex subunit 3 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AL671489

  12. NM_001411772.1 → NP_001398701.1  MSL complex subunit 3 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AL671489

  13. NM_010832.6 → NP_034962.2  MSL complex subunit 3 isoform 5

    See identical proteins and their annotated locations for NP_034962.2

    Status: VALIDATED

    Source sequence(s)
    AL671489
    Consensus CDS
    CCDS41211.1
    UniProtKB/Swiss-Prot
    Q9WVG9
    Related
    ENSMUSP00000107765.2, ENSMUST00000112137.2
    Conserved Domains (3) summary
    pfam05712
    Location:117 → 451
    MRG
    pfam12258
    Location:254 → 353
    Microcephalin; Microcephalin protein
    cl28914
    Location:3 → 22
    CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    167434263..167456868 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161839.1 → XP_036017732.1  male-specific lethal 3 homolog isoform X4

    Conserved Domains (1) summary
    pfam05712
    Location:5 → 340
    MRG
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WVG9.3 GenPept UniProtKB/Swiss-Prot:Q9WVG9

Gene LinkOut

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