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Msl3 MSL complex subunit 3 [ Mus musculus (house mouse) ]

Gene ID: 17692, updated on 2-Jun-2024

Summary

Official Symbol
Msl3provided by MGI
Official Full Name
MSL complex subunit 3provided by MGI
Primary source
MGI:MGI:1341851
See related
Ensembl:ENSMUSG00000031358 AllianceGenome:MGI:1341851
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Msl31; Msl3l1
Summary
Predicted to enable DNA binding activity; histone acetyltransferase activity (H4-K16 specific); and methylated histone binding activity. Predicted to be involved in heterochromatin assembly and histone modification. Predicted to act upstream of or within chromatin organization. Predicted to be located in nucleus. Predicted to be part of MSL complex and NuA4 histone acetyltransferase complex. Is expressed in embryo; limb; and limb mesenchyme. Human ortholog(s) of this gene implicated in Basilicata-Akhtar syndrome. Orthologous to human MSL3 (MSL complex subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 7.1), placenta adult (RPKM 6.4) and 28 other tissues See more
Orthologs
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Genomic context

See Msl3 in Genome Data Viewer
Location:
X F5; X 78.73 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (167434263..167456868, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (168651267..168674354, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene FERM and PDZ domain containing 4 Neighboring gene STARR-seq mESC enhancer starr_48277 Neighboring gene predicted pseudogene 7209 Neighboring gene STARR-positive B cell enhancer mm9_chrX:165110350-165110651 Neighboring gene STARR-seq mESC enhancer starr_48278 Neighboring gene predicted gene, 39550 Neighboring gene STARR-seq mESC enhancer starr_48279 Neighboring gene Rho GTPase activating protein 6 Neighboring gene STARR-seq mESC enhancer starr_48280 Neighboring gene STARR-positive B cell enhancer mm9_chrX:165523946-165524246 Neighboring gene STARR-seq mESC enhancer starr_48281 Neighboring gene amelogenin, X-linked Neighboring gene holocytochrome c synthetase

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables histone H4K16 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables methylated histone binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
 
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of MSL complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of MSL complex ISO
Inferred from Sequence Orthology
more info
 
part_of NuA4 histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
MSL complex subunit 3; male-specific lethal 3 homolog
Names
male-specific lethal-3 homolog 1
male-specific lethal-3 protein-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001370791.1NP_001357720.1  MSL complex subunit 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL671489
    Consensus CDS
    CCDS90775.1
    UniProtKB/Swiss-Prot
    B1AUJ7, B1AUJ8, Q9WVG9
    Related
    ENSMUSP00000033725.10, ENSMUST00000033725.16
    Conserved Domains (3) summary
    cd18983
    Location:1581
    CBD_MSL3_like; chromo barrel domain of human male-specific lethal complex subunit 3, and similar proteins
    pfam05712
    Location:176510
    MRG
    pfam12258
    Location:313412
    Microcephalin; Microcephalin protein
  2. NM_001370792.1NP_001357721.1  MSL complex subunit 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL671489
    Conserved Domains (3) summary
    cd18983
    Location:1581
    CBD_MSL3_like; chromo barrel domain of human male-specific lethal complex subunit 3, and similar proteins
    pfam05712
    Location:175509
    MRG
    pfam12258
    Location:312411
    Microcephalin; Microcephalin protein
  3. NM_001370793.1NP_001357722.1  MSL complex subunit 3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL671489
    Conserved Domains (3) summary
    pfam05712
    Location:154488
    MRG
    pfam12258
    Location:291390
    Microcephalin; Microcephalin protein
    cl28914
    Location:1259
    CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains
  4. NM_001370794.1NP_001357723.1  MSL complex subunit 3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL671489
    Conserved Domains (3) summary
    cd18983
    Location:1581
    CBD_MSL3_like; chromo barrel domain of human male-specific lethal complex subunit 3, and similar proteins
    pfam05712
    Location:175499
    MRG
    pfam12258
    Location:312411
    Microcephalin; Microcephalin protein
  5. NM_001370795.1NP_001357724.1  MSL complex subunit 3 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL671489
    Conserved Domains (3) summary
    pfam05712
    Location:116450
    MRG
    pfam12258
    Location:253352
    Microcephalin; Microcephalin protein
    cl28914
    Location:322
    CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains
  6. NM_001370796.1NP_001357725.1  MSL complex subunit 3 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL671489
    Conserved Domains (3) summary
    pfam05712
    Location:117441
    MRG
    pfam12258
    Location:254353
    Microcephalin; Microcephalin protein
    cl28914
    Location:322
    CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains
  7. NM_001370797.1NP_001357726.1  MSL complex subunit 3 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL671489
    Conserved Domains (3) summary
    pfam05712
    Location:116440
    MRG
    pfam12258
    Location:253352
    Microcephalin; Microcephalin protein
    cl28914
    Location:322
    CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains
  8. NM_001370798.1NP_001357727.1  MSL complex subunit 3 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AL671489
    Conserved Domains (3) summary
    pfam05712
    Location:120426
    MRG
    pfam12258
    Location:229328
    Microcephalin; Microcephalin protein
    cl28914
    Location:322
    CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains
  9. NM_001370799.1NP_001357728.1  MSL complex subunit 3 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AL671489
    Conserved Domains (3) summary
    pfam05712
    Location:117241
    MRG
    pfam12258
    Location:254353
    Microcephalin; Microcephalin protein
    cl28914
    Location:322
    CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains
  10. NM_001411770.1NP_001398699.1  MSL complex subunit 3 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AL671489
  11. NM_001411771.1NP_001398700.1  MSL complex subunit 3 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AL671489
  12. NM_001411772.1NP_001398701.1  MSL complex subunit 3 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AL671489
  13. NM_010832.6NP_034962.2  MSL complex subunit 3 isoform 5

    See identical proteins and their annotated locations for NP_034962.2

    Status: VALIDATED

    Source sequence(s)
    AL671489
    Consensus CDS
    CCDS41211.1
    UniProtKB/Swiss-Prot
    Q9WVG9
    Related
    ENSMUSP00000107765.2, ENSMUST00000112137.2
    Conserved Domains (3) summary
    pfam05712
    Location:117451
    MRG
    pfam12258
    Location:254353
    Microcephalin; Microcephalin protein
    cl28914
    Location:322
    CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    167434263..167456868 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161839.1XP_036017732.1  male-specific lethal 3 homolog isoform X4

    Conserved Domains (1) summary
    pfam05712
    Location:5340
    MRG