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DNAH8 dynein axonemal heavy chain 8 [ Homo sapiens (human) ]

Gene ID: 1769, updated on 19-Jul-2021

Summary

Official Symbol
DNAH8provided by HGNC
Official Full Name
dynein axonemal heavy chain 8provided by HGNC
Primary source
HGNC:HGNC:2952
See related
Ensembl:ENSG00000124721 MIM:603337
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
hdhc9; ATPase; SPGF46
Summary
The protein encoded by this gene is a heavy chain of an axonemal dynein involved in sperm and respiratory cilia motility. Axonemal dyneins generate force through hydrolysis of ATP and binding to microtubules. [provided by RefSeq, Jan 2012]
Expression
Biased expression in testis (RPKM 4.6), prostate (RPKM 0.5) and 2 other tissues See more
Orthologs
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Genomic context

See DNAH8 in Genome Data Viewer
Location:
6p21.2
Exon count:
97
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (38715311..39030798)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (38683087..38998568)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene BTB domain containing 9 Neighboring gene uncharacterized LOC105375044 Neighboring gene glyoxalase I Neighboring gene RNA, 7SL, cytoplasmic 465, pseudogene Neighboring gene DnaJ heat shock protein family (Hsp40) member C2 pseudogene Neighboring gene DNAH8 antisense RNA 1 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene uncharacterized LOC105375046 Neighboring gene microRNA 9983 Neighboring gene glucagon like peptide 1 receptor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of dynein, axonemal, heavy chain 8 (DNAH8) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ25850, FLJ36115, FLJ36334

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables dynein intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables dynein light intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables microtubule motor activity NAS
Non-traceable Author Statement
more info
PubMed 
enables minus-end-directed microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in cilium-dependent cell motility NAS
Non-traceable Author Statement
more info
PubMed 
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in outer dynein arm assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of axonemal dynein complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in axoneme IDA
Inferred from Direct Assay
more info
PubMed 
part_of dynein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
part_of outer dynein arm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in sperm flagellum IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
dynein axonemal heavy chain 8; dynein heavy chain 8, axonemal
Names
axonemal beta dynein heavy chain 8
ciliary dynein heavy chain 8
dynein, axonemal, heavy polypeptide 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_041805.1 RefSeqGene

    Range
    4971..320452
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001206927.2NP_001193856.1  dynein axonemal heavy chain 8 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF356519, AF527621, AL034345, AL035555, AL035690, AL353700, AL391415
    Consensus CDS
    CCDS75447.1
    UniProtKB/Swiss-Prot
    Q96JB1
    UniProtKB/TrEMBL
    A0A075B6F3, Q8IU65
    Related
    ENSP00000333363.7, ENST00000327475.11
    Conserved Domains (7) summary
    pfam03028
    Location:40144696
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08385
    Location:354910
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:14881891
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12777
    Location:32823628
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:36573873
    AAA_9; ATP-binding dynein motor region D5
    pfam15297
    Location:9151047
    CKAP2_C; Cytoskeleton-associated protein 2 C-terminus
    cl21455
    Location:20252256
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. NM_001371.4NP_001362.2  dynein axonemal heavy chain 8 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL034345, AL035555, AL035690, AL353700, AL391415
    Related
    ENSP00000352312.3, ENST00000359357.7
    Conserved Domains (5) summary
    pfam03028
    Location:37994486
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08385
    Location:139693
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:12751673
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam15297
    Location:698830
    CKAP2_C; Cytoskeleton-associated protein 2 C-terminus
    cl25937
    Location:11174138
    MT; Microtubule-binding stalk of dynein motor

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    38715311..39030798
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017010327.1XP_016865816.1  dynein heavy chain 8, axonemal isoform X7

  2. XM_011514319.2XP_011512621.1  dynein heavy chain 8, axonemal isoform X2

    Conserved Domains (7) summary
    pfam03028
    Location:39784660
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08385
    Location:354910
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:14881891
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12777
    Location:32463592
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:36213837
    AAA_9; ATP-binding dynein motor region D5
    pfam15297
    Location:9151047
    CKAP2_C; Cytoskeleton-associated protein 2 C-terminus
    cl21455
    Location:29623233
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  3. XM_011514318.2XP_011512620.1  dynein heavy chain 8, axonemal isoform X1

    Conserved Domains (7) summary
    pfam03028
    Location:39934675
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08385
    Location:354910
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:14671870
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12777
    Location:32613607
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:36363852
    AAA_9; ATP-binding dynein motor region D5
    pfam15297
    Location:9151047
    CKAP2_C; Cytoskeleton-associated protein 2 C-terminus
    cl21455
    Location:20042235
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  4. XM_011514320.2XP_011512622.1  dynein heavy chain 8, axonemal isoform X3

    Conserved Domains (7) summary
    pfam03028
    Location:39354617
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08385
    Location:275831
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:14091812
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12777
    Location:32033549
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:35783794
    AAA_9; ATP-binding dynein motor region D5
    pfam15297
    Location:836968
    CKAP2_C; Cytoskeleton-associated protein 2 C-terminus
    cl21455
    Location:19462177
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  5. XM_017010325.1XP_016865814.1  dynein heavy chain 8, axonemal isoform X5

  6. XM_017010326.1XP_016865815.1  dynein heavy chain 8, axonemal isoform X6

    Related
    ENSP00000415331.2, ENST00000449981.6

RNA

  1. XR_001743188.1 RNA Sequence

  2. XR_926078.2 RNA Sequence

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