Format

Send to:

Choose Destination

Msh6 mutS homolog 6 [ Mus musculus (house mouse) ]

Gene ID: 17688, updated on 9-Sep-2018

Summary

Official Symbol
Msh6provided by MGI
Official Full Name
mutS homolog 6provided by MGI
Primary source
MGI:MGI:1343961
See related
Ensembl:ENSMUSG00000005370
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GTBP; Gtmbp; AU044881; AW550279
Expression
Broad expression in CNS E11.5 (RPKM 17.1), liver E14 (RPKM 9.0) and 23 other tissues See more
Orthologs

Genomic context

See Msh6 in Genome Data Viewer
Location:
17 E4; 17 57.87 cM
Exon count:
10
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (87975050..87990892)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (88374390..88390232)

Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 41649 Neighboring gene ribosomal protein L36, pseudogene 4 Neighboring gene F-box protein 11 Neighboring gene predicted gene, 45950 Neighboring gene predicted gene 4832

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Chemically induced (ENU) (1) 

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to ADP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to ADP binding ISO
Inferred from Sequence Orthology
more info
 
ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to ATP binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to ATPase activity ISO
Inferred from Sequence Orthology
more info
 
DNA binding IGI
Inferred from Genetic Interaction
more info
PubMed 
DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
DNA-dependent ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to MutLalpha complex binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to MutLalpha complex binding ISO
Inferred from Sequence Orthology
more info
 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
damaged DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
damaged DNA binding IGI
Inferred from Genetic Interaction
more info
PubMed 
damaged DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
contributes_to double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
four-way junction DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to four-way junction DNA binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to guanine/thymine mispair binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
guanine/thymine mispair binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to guanine/thymine mispair binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to guanine/thymine mispair binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to magnesium ion binding ISO
Inferred from Sequence Orthology
more info
 
methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
methylated histone binding ISO
Inferred from Sequence Orthology
more info
 
mismatched DNA binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to mismatched DNA binding ISO
Inferred from Sequence Orthology
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to oxidized purine DNA binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to single guanine insertion binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to single thymine insertion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to single thymine insertion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
DNA repair ISO
Inferred from Sequence Orthology
more info
 
cellular response to DNA damage stimulus IEA
Inferred from Electronic Annotation
more info
 
determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
PubMed 
interstrand cross-link repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
intrinsic apoptotic signaling pathway in response to DNA damage IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intrinsic apoptotic signaling pathway in response to DNA damage IMP
Inferred from Mutant Phenotype
more info
PubMed 
isotype switching IMP
Inferred from Mutant Phenotype
more info
PubMed 
maintenance of DNA repeat elements IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
meiotic mismatch repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mismatch repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mismatch repair IGI
Inferred from Genetic Interaction
more info
PubMed 
mismatch repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
mismatch repair ISO
Inferred from Sequence Orthology
more info
PubMed 
mitotic G2 DNA damage checkpoint IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of DNA endoreduplication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of DNA recombination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of DNA recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of DNA recombination ISO
Inferred from Sequence Orthology
more info
 
positive regulation of helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of helicase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of isotype switching IGI
Inferred from Genetic Interaction
more info
PubMed 
pyrimidine dimer repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
replication fork arrest IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to UV IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to UV IMP
Inferred from Mutant Phenotype
more info
PubMed 
somatic hypermutation of immunoglobulin genes IMP
Inferred from Mutant Phenotype
more info
PubMed 
somatic recombination of immunoglobulin gene segments IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
MutSalpha complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
MutSalpha complex IDA
Inferred from Direct Assay
more info
PubMed 
MutSalpha complex ISO
Inferred from Sequence Orthology
more info
 
chromosome IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
intracellular IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
mismatch repair complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear chromatin IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
DNA mismatch repair protein Msh6
Names
g/T mismatch-binding protein
mutS protein homolog 6
mutS-alpha 160 kDa subunit
p160

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010830.2NP_034960.1  DNA mismatch repair protein Msh6

    See identical proteins and their annotated locations for NP_034960.1

    Status: VALIDATED

    Source sequence(s)
    BC051634, CN458717
    Consensus CDS
    CCDS29021.1
    UniProtKB/Swiss-Prot
    P54276
    Related
    ENSMUSP00000005503.3, ENSMUST00000005503.3
    Conserved Domains (8) summary
    cd05837
    Location:88195
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    COG0249
    Location:4061330
    MutS; DNA mismatch repair ATPase MutS [Replication, recombination and repair]
    pfam01624
    Location:406524
    MutS_I; MutS domain I
    pfam05188
    Location:537689
    MutS_II; MutS domain II
    pfam05190
    Location:9291021
    MutS_IV; MutS family domain IV
    pfam05192
    Location:736824
    MutS_III; MutS domain III
    pfam14797
    Location:224349
    SEEEED; Serine-rich region of AP3B1, clathrin-adaptor complex
    cl21455
    Location:10891311
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

    Range
    87975050..87990892
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center