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uncp-18 Syntaxin-binding protein 1 [ Caenorhabditis elegans ]

Gene ID: 176862, updated on 23-Nov-2023

Summary

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Gene symbol
uncp-18
Gene description
Syntaxin-binding protein 1
Primary source
WormBase:WBGene00020298
Locus tag
CELE_T07A9.10
See related
AllianceGenome:WB:WBGene00020298
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable syntaxin binding activity. Predicted to be involved in intracellular protein transport; neurotransmitter secretion; and vesicle docking involved in exocytosis. Predicted to be located in presynapse. Predicted to be active in plasma membrane and secretory granule. Orthologous to human STXBP3 (syntaxin binding protein 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: IV
Exon count:
8
Sequence:
Chromosome: IV; NC_003282.8 (390560..393158)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Remorin_N domain-containing protein Neighboring gene Sjogren's Syndrome Nuclear Autoantigen Neighboring gene putative glutamate--tRNA ligase, mitochondrial Neighboring gene Cytochrome c oxidase assembly protein COX14 Neighboring gene Nucleolar GTP-binding protein 1 Neighboring gene Ribosomal RNA-processing protein 8

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
  2. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables syntaxin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neurotransmitter secretion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle docking involved in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in presynapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in secretory granule IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Syntaxin-binding protein 1
NP_499918.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    390560..393158
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067517.7 → NP_499918.1  Syntaxin-binding protein 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499918.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O44412
    Conserved Domains (1) summary
    pfam00995
    Location:31 → 547
    Sec1; Sec1 family
Nucleotide Protein
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