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Msh3 mutS homolog 3 [ Mus musculus (house mouse) ]

Gene ID: 17686, updated on 8-Nov-2022

Summary

Official Symbol
Msh3provided by MGI
Official Full Name
mutS homolog 3provided by MGI
Primary source
MGI:MGI:109519
See related
Ensembl:ENSMUSG00000014850 AllianceGenome:MGI:109519
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rep3; REP-1; Rep-3; D13Em1
Summary
Enables centromeric DNA binding activity and damaged DNA binding activity. Acts upstream of or within mismatch repair and somatic recombination of immunoglobulin gene segments. Predicted to be located in nucleus. Predicted to be part of MutSbeta complex. Is expressed in early conceptus; oocyte; and secondary oocyte. Human ortholog(s) of this gene implicated in colorectal carcinoma; endometrial cancer; endometrial carcinoma; familial adenomatous polyposis 4; and lung non-small cell carcinoma. Orthologous to human MSH3 (mutS homolog 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 5.6), CNS E14 (RPKM 4.6) and 25 other tissues See more
Orthologs
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Genomic context

See Msh3 in Genome Data Viewer
Location:
13 C3; 13 47.63 cM
Exon count:
25
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (92348386..92491513, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (92211878..92355004, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene creatine kinase, mitochondrial 2 Neighboring gene RAS protein-specific guanine nucleotide-releasing factor 2 Neighboring gene predicted gene, 46435 Neighboring gene predicted gene, 20379 Neighboring gene 60S ribosomal protein L32 pseudogene Neighboring gene dihydrofolate reductase Neighboring gene ankyrin repeat domain 34B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP-dependent DNA damage sensor activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA binding IGI
Inferred from Genetic Interaction
more info
PubMed 
enables centromeric DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables damaged DNA binding IGI
Inferred from Genetic Interaction
more info
PubMed 
contributes_to dinucleotide insertion or deletion binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to dinucleotide repeat insertion binding ISO
Inferred from Sequence Orthology
more info
 
enables double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to mismatched DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to single guanine insertion binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to single-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of MutSbeta complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
DNA mismatch repair protein Msh3
Names
protein repair-1
protein repair-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001311120.2NP_001298049.1  DNA mismatch repair protein Msh3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC155263, AC161588
    Consensus CDS
    CCDS79222.1
    UniProtKB/TrEMBL
    E9QPY6
    Related
    ENSMUSP00000022220.8, ENSMUST00000022220.13
    Conserved Domains (6) summary
    COG0249
    Location:1831052
    MutS; DNA mismatch repair ATPase MutS [Replication, recombination and repair]
    pfam00488
    Location:8041051
    MutS_V; MutS domain V
    pfam01624
    Location:188301
    MutS_I; MutS domain I
    pfam05188
    Location:324481
    MutS_II; MutS domain II
    pfam05192
    Location:498613
    MutS_III; MutS domain III
    cl17822
    Location:670755
    MutS_III; MutS domain III
  2. NM_010829.3NP_034959.2  DNA mismatch repair protein Msh3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC155263, AC161588
    Consensus CDS
    CCDS49326.1
    UniProtKB/Swiss-Prot
    P13705
    UniProtKB/TrEMBL
    A0A087WQ16
    Related
    ENSMUSP00000140002.2, ENSMUST00000185852.7
    Conserved Domains (6) summary
    COG0249
    Location:1831053
    MutS; DNA mismatch repair ATPase MutS [Replication, recombination and repair]
    pfam00488
    Location:8041052
    MutS_V; MutS domain V
    pfam01624
    Location:188301
    MutS_I; MutS domain I
    pfam05188
    Location:324481
    MutS_II; MutS domain II
    pfam05192
    Location:498613
    MutS_III; MutS domain III
    cl17822
    Location:670755
    MutS_III; MutS domain III

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    92348386..92491513 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157896.1XP_036013789.1  DNA mismatch repair protein Msh3 isoform X2

    Conserved Domains (1) summary
    COG0249
    Location:3736
    MutS; DNA mismatch repair ATPase MutS [Replication, recombination and repair]
  2. XM_036157897.1XP_036013790.1  DNA mismatch repair protein Msh3 isoform X2

    Conserved Domains (1) summary
    COG0249
    Location:3736
    MutS; DNA mismatch repair ATPase MutS [Replication, recombination and repair]
  3. XM_017315412.3XP_017170901.1  DNA mismatch repair protein Msh3 isoform X2

    Conserved Domains (1) summary
    COG0249
    Location:3736
    MutS; DNA mismatch repair ATPase MutS [Replication, recombination and repair]
  4. XM_006517543.2XP_006517606.1  DNA mismatch repair protein Msh3 isoform X1

    See identical proteins and their annotated locations for XP_006517606.1

    Conserved Domains (1) summary
    COG0249
    Location:1857
    MutS; DNA mismatch repair ATPase MutS [Replication, recombination and repair]
  5. XM_006517542.2XP_006517605.1  DNA mismatch repair protein Msh3 isoform X1

    See identical proteins and their annotated locations for XP_006517605.1

    Conserved Domains (1) summary
    COG0249
    Location:1857
    MutS; DNA mismatch repair ATPase MutS [Replication, recombination and repair]
  6. XM_017315413.2XP_017170902.1  DNA mismatch repair protein Msh3 isoform X2

    Conserved Domains (1) summary
    COG0249
    Location:3736
    MutS; DNA mismatch repair ATPase MutS [Replication, recombination and repair]

RNA

  1. XR_004937944.1 RNA Sequence

    Related
    ENSMUST00000191550.7