cul-2 Cullin-2 [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: cul-2
Gene description: Cullin-2
Primary source: WormBase:WBGene00000837
Locus tag: CELE_ZK520.4
See related: AllianceGenome:WB:WBGene00000837
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ubiquitin protein ligase binding activity and ubiquitin-protein transferase activity. Involved in several processes, including male sex determination; meiotic chromosome segregation; and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in cytoplasm and nucleus. Part of Cul2-RING ubiquitin ligase complex. Is expressed in several structures, including P1; P10; P11; germ line; and nerve ring. Orthologous to human CUL2 (cullin 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See cul-2 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 9

Sequence:: Chromosome: III; NC_003281.10 (13687269..13692683)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CUL-2(LRR-1) and UBXN-3 drive replisome disassembly during DNA replication termination and mitosis.
Title: CUL-2(LRR-1) and UBXN-3 drive replisome disassembly during DNA replication termination and mitosis.
CUL-2 RING E3 ubiquitin-ligase acts at multiple levels to control germline development; CUL-2 may similarly regulate germline development in other organisms as well.
Title: CRL2(LRR-1) E3-ligase regulates proliferation and progression through meiosis in the Caenorhabditis elegans germline.
Results indicate that LRR-1 acts as a nuclear substrate-recognition subunit of a Cullin 2-RING E3 ligase complex (CRL2(LRR-1)), which ensures DNA replication integrity.
Title: The CRL2LRR-1 ubiquitin ligase regulates cell cycle progression during C. elegans development.
The C. elegans p97/CDC-48-UFD-1-NPL-4 complex controls the sperm-oocyte switch by regulating CUL-2-mediated TRA-1A proteasome degradation.
Title: Caenorhabditis elegans p97 controls germline-specific sex determination by controlling the TRA-1 level in a CUL-2-dependent manner.
MEL-26 levels are kept low by the action of another type of ubiquitin ligase, which contains CUL-2
Title: Levels of the ubiquitin ligase substrate adaptor MEL-26 are inversely correlated with MEI-1/katanin microtubule-severing activity during both meiosis and mitosis.
Fem-1 protein is a substrate-specific adaptor for a CUL-2-based ubiquitin ligase.
Title: PAR-6 levels are regulated by NOS-3 in a CUL-2 dependent manner in Caenorhabditiselegans.
segregation of the germ plasm involves both stabilization of germline proteins in the germ line and cullin-dependent degradation in the soma
Title: Exclusion of germ plasm proteins from somatic lineages by cullin-dependent degradation.
Results establish that zyg-11 and the cullin cul-2 promote the metaphase-to-anaphase transition and M phase exit at meiosis II in Caenorhabditis elegans.
Title: Zyg-11 and cul-2 regulate progression through meiosis II and polarity establishment in C. elegans.
Data show that inactivation of ZYG-11 produces meiotic and polarity reversal defects similar to those observed in CUL-2 mutants, suggesting that the two proteins function in the same pathways.
Title: CUL-2 and ZYG-11 promote meiotic anaphase II and the proper placement of the anterior-posterior axis in C. elegans.
oocyte maturation from pachytene exit and MPK-1 activation are redundantly controlled by the RBX-2-CUL-5- and RBX-1-CUL-2-based complexes.
Title: C. elegans RBX-2-CUL-5- and RBX-1-CUL-2-based complexes are redundant for oogenesis and activation of the MAP kinase MPK-1.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ZK520.4 (e-PCR)
- UniSTS:310504

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-macromolecule adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in anaphase-promoting complex-dependent catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in anterior/posterior axis specification, embryo	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell cycle	IEA Inferred from Electronic Annotation more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in chromosome condensation	IEA Inferred from Electronic Annotation more info
involved_in germ-line stem cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male germ-line sex determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male somatic sex determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic spindle elongation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of metaphase/anaphase transition of meiotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in sister chromosome movement towards spindle pole involved in meiotic sister chromatid segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of Cul2-RING ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Cul2-RING ubiquitin ligase complex	IDA Inferred from Direct Assay more info	PubMed
part_of SCF ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Cullin-2

NP_001023007.1

Confirmed by transcript evidence

NP_001023008.1

Confirmed by transcript evidence

NP_001367020.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

13687269..13692683

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001027836.6 → NP_001023007.1 Cullin-2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001023007.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q17390

Conserved Domains (3) summary

smart00182
Location:441 → 599

CULLIN; Cullin

smart00884
Location:702 → 767

Cullin_Nedd8; Cullin protein neddylation domain

pfam00888
Location:17 → 645

Cullin; Cullin family
NM_001027837.3 → NP_001023008.1 Cullin-2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001023008.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O46021, Q17390, Q8I4A7, Q8WQ96, Q9NA22

Conserved Domains (2) summary

smart00884
Location:719 → 784

Cullin_Nedd8; Cullin protein neddylation domain

pfam00888
Location:32 → 662

Cullin; Cullin family
NM_001379988.2 → NP_001367020.1 Cullin-2 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (2) summary

pfam00888
Location:15 → 612

Cullin; Cullin family

pfam10557
Location:674 → 735

Cullin_Nedd8; Cullin protein neddylation domain