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mlh-1 DNA mismatch repair protein S5 domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 176783, updated on 23-Nov-2023

Summary

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Gene symbol
mlh-1
Gene description
DNA mismatch repair protein S5 domain-containing protein
Primary source
WormBase:WBGene00003373
Locus tag
CELE_T28A8.7
See related
AllianceGenome:WB:WBGene00003373
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ATP hydrolysis activity. Predicted to be involved in mismatch repair. Predicted to be located in nucleus. Predicted to be part of MutLalpha complex. Human ortholog(s) of this gene implicated in Lynch syndrome (multiple); gastrointestinal system cancer (multiple); lung cancer; mismatch repair cancer syndrome; and sporadic breast cancer. Orthologous to human MLH1 (mutL homolog 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: III
Exon count:
8
Sequence:
Chromosome: III; NC_003281.10 (13509301..13514570, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene SPK domain-containing protein Neighboring gene SPK domain-containing protein Neighboring gene DUF1899 domain-containing protein Neighboring gene tRNA Neighboring gene tRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Base excision repair AP endonucleases and mismatch repair act together to induce checkpoint-mediated autophagy. SenGupta T, et al. Nat Commun, 2013. PMID 24154628, Free PMC Article
  2. Frequent germline mutations and somatic repeat instability in DNA mismatch-repair-deficient Caenorhabditis elegans. Tijsterman M, et al. Genetics, 2002 Jun. PMID 12072462, Free PMC Article
  3. DOG-1 is the Caenorhabditis elegans BRIP1/FANCJ homologue and functions in interstrand cross-link repair. Youds JL, et al. Mol Cell Biol, 2008 Mar. PMID 18086896, Free PMC Article
  4. Chlorpyrifos exposure reduces reproductive capacity owing to a damaging effect on gametogenesis in the nematode Caenorhabditis elegans. Ruan QL, et al. J Appl Toxicol, 2012 Jul. PMID 22180373
  5. Combined functional genomic maps of the C. elegans DNA damage response. Boulton SJ, et al. Science, 2002 Jan 4. PMID 11778048

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent DNA damage sensor activity IEA
Inferred from Electronic Annotation
more info
  
enables mismatched DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage response IEA
Inferred from Electronic Annotation
more info
  
involved_in mismatch repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mismatch repair IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of MutLalpha complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular organelle IEA
Inferred from Electronic Annotation
more info
  
part_of mismatch repair complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DNA mismatch repair protein S5 domain-containing protein
NP_499796.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    13509301..13514570 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067395.7 → NP_499796.2  DNA mismatch repair protein S5 domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499796.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9XU10
    Conserved Domains (2) summary
    TIGR00585
    Location:2 → 316
    mutl; DNA mismatch repair protein MutL
    pfam16413
    Location:501 → 756
    Mlh1_C; DNA mismatch repair protein Mlh1 C-terminus
Nucleotide Protein
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