U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

qdpr-1 Dihydropteridine reductase dhpr/qdpr [ Caenorhabditis elegans ]

Gene ID: 176762, updated on 23-Nov-2023

Summary

Go to the top of the page Help
Gene symbol
qdpr-1
Gene description
Dihydropteridine reductase dhpr/qdpr
Primary source
WormBase:WBGene00011398
Locus tag
CELE_T03F6.1
See related
AllianceGenome:WB:WBGene00011398
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable 6,7-dihydropteridine reductase activity; NADH binding activity; and NADPH binding activity. Predicted to be involved in L-phenylalanine catabolic process and tetrahydrobiopterin biosynthetic process. Predicted to be active in cytoplasm. Is expressed in gonad; head; hypodermis; neurons; and tail. Human ortholog(s) of this gene implicated in phenylketonuria. Orthologous to human QDPR (quinoid dihydropteridine reductase). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: III
Exon count:
5
Sequence:
Chromosome: III; NC_003281.10 (13393910..13394979)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene F-box domain-containing protein Neighboring gene putative glucosamine-6-phosphate isomerase Neighboring gene J domain-containing protein Neighboring gene DUF148 domain-containing protein;SXP/RAL-2 family protein Ani s 5-like cation-binding domain-containing protein Neighboring gene pseudo Neighboring gene SXP/RAL-2 family protein Ani s 5-like cation-binding domain-containing protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Cuticle integrity and biogenic amine synthesis in Caenorhabditis elegans require the cofactor tetrahydrobiopterin (BH4). Loer CM, et al. Genetics, 2015 May. PMID 25808955, Free PMC Article
  2. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
  3. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
  4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables 6,7-dihydropteridine reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NADH binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NADPH binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-phenylalanine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tetrahydrobiopterin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Dihydropteridine reductase dhpr/qdpr
NP_499760.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    13393910..13394979
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067359.7 → NP_499760.1  Dihydropteridine reductase dhpr/qdpr [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499760.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9XVJ3
    Conserved Domains (1) summary
    cd05334
    Location:3 → 226
    DHPR_SDR_c_like; dihydropteridine reductase (DHPR), classical (c) SDRs
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
1OOE_A.1
1OOE_B.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous