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klp-19 Kinesin motor domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 176750, updated on 4-Nov-2022

Summary

Gene symbol
klp-19
Gene description
Kinesin motor domain-containing protein
Primary source
WormBase:WBGene00002229
Locus tag
CELE_Y43F4B.6
See related
AllianceGenome:WB:WBGene00002229
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Involved in meiotic chromosome condensation and meiotic spindle midzone assembly. Located in condensed nuclear chromosome; nucleoplasm; and spindle. Is expressed in germ line. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 100. Orthologous to several human genes including KIF4A (kinesin family member 4A). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See klp-19 in Genome Data Viewer
Location:
chromosome: III
Exon count:
7
Sequence:
Chromosome: III; NC_003281.10 (13302717..13307259, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Histone-lysine N-methyltransferase set-25 Neighboring gene ncRNA Neighboring gene Nucleoporin SEH1 Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Aa_trans domain-containing protein Neighboring gene Uncharacterized protein

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
 
enables microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables microtubule motor activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in meiotic chromosome condensation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in meiotic spindle midzone assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in microtubule-based movement IEA
Inferred from Electronic Annotation
more info
 
involved_in microtubule-based process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in chromosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in condensed nuclear chromosome IDA
Inferred from Direct Assay
more info
PubMed 
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in spindle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
Kinesin motor domain-containing protein
NP_499742.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    13302717..13307259 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067341.4NP_499742.1  Kinesin motor domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499742.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O45935
    UniProtKB/TrEMBL
    O45935
    Conserved Domains (3) summary
    COG1196
    Location:481825
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02169
    Location:342621
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    cd00106
    Location:6326
    KISc; Kinesin motor domain