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orc-1 Origin recognition complex subunit 1 [ Caenorhabditis elegans ]

Gene ID: 176486, updated on 23-Nov-2023

Summary

Gene symbol
orc-1
Gene description
Origin recognition complex subunit 1
Primary source
WormBase:WBGene00012650
Locus tag
CELE_Y39A1A.12
See related
AllianceGenome:WB:WBGene00012650
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA replication origin binding activity. Predicted to be involved in DNA replication initiation and mitotic DNA replication checkpoint signaling. Predicted to be located in nucleus. Predicted to be part of nuclear origin of replication recognition complex. Is expressed in germ line. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 1. Orthologous to human ORC1 (origin recognition complex subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See orc-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
4
Sequence:
Chromosome: III; NC_003281.10 (10643129..10646058)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Nematode Specific Peptide family, group C Neighboring gene Estradiol 17-beta-dehydrogenase 8;Estradiol 17-beta-dehydrogenase 8-like Neighboring gene ORC (Origin Recognition Complex) subunit Neighboring gene Ribosomal RNA small subunit methyltransferase nep-1

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA replication origin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitotic DNA replication checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of nuclear origin of replication recognition complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Origin recognition complex subunit 1
NP_499347.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    10643129..10646058
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066946.7NP_499347.1  Origin recognition complex subunit 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499347.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9XX17
    Conserved Domains (3) summary
    smart01074
    Location:542623
    Cdc6_C; CDC6, C terminal
    PRK00411
    Location:263630
    cdc6; cell division control protein 6; Reviewed
    pfam00004
    Location:295447
    AAA; ATPase family associated with various cellular activities (AAA)