sip-1 Stress-induced protein 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: sip-1
Official Full Name: Stress-induced protein 1
Primary source: WormBase:WBGene00004798
Locus tag: CELE_F43D9.4
See related: AllianceGenome:WB:WBGene00004798
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable unfolded protein binding activity. Involved in determination of adult lifespan; embryo development; and response to heat. Located in cytosol. Is expressed in body wall musculature; gonad; and intestine. [provided by Alliance of Genome Resources, Jul 2025]
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Genomic context

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See sip-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 2

Sequence:: Chromosome: III; NC_003281.10 (10506106..10506801, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate that the oligomeric distribution of small heat shock protein Sip1 as well as its chaperone activity depend on pH, with a trend toward smaller species and higher activity at acidic conditions.
Title: The Chaperone Activity of the Developmental Small Heat Shock Protein Sip1 Is Regulated by pH-Dependent Conformational Changes.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F43D9.4 (e-PCR)
- UniSTS:320973

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables unfolded protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables unfolded protein binding	IC Inferred by Curator more info	PubMed

Process	Evidence Code	Pubs
involved_in determination of adult lifespan	IEP Inferred from Expression Pattern more info	PubMed
involved_in determination of adult lifespan	IGI Inferred from Genetic Interaction more info	PubMed
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein refolding	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to heat	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to heat	IEA Inferred from Electronic Annotation more info
involved_in response to heat	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Stress-induced protein 1

NP_499316.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

10506106..10506801 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_066915.5 → NP_499316.1 Stress-induced protein 1

See identical proteins and their annotated locations for NP_499316.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q20363

Conserved Domains (1) summary

cd06526
Location:45 → 126

metazoan_ACD; Alpha-crystallin domain (ACD) of metazoan alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are ...