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alx-1 Apoptosis-linked gene 2-interacting protein X 1 [ Caenorhabditis elegans ]

Gene ID: 176410, updated on 5-Sep-2019

Summary

Gene symbol
alx-1
Gene description
Apoptosis-linked gene 2-interacting protein X 1
Primary source
WormBase:WBGene00007010
Locus tag
CELE_R10E12.1
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis

Genomic context

See alx-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
9
Sequence:
Chromosome: III; NC_003281.10 (9957351..9963132)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Probable pre-mRNA-splicing factor ATP-dependent RNA helicase mog-1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene hypothetical protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Pathways from BioSystems

  • Endocytosis, organism-specific biosystem (from KEGG)
    Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Endocytosis, conserved biosystem (from KEGG)
    Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

  • Homologs of the alx-1 gene: The alx-1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, S.cerevisiae, K.lactis, E.gossypii, M.oryzae, N.crassa, A.thaliana, rice, and frog.
  • Orthologs

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
Notch binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein C-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
endocytic recycling IMP
Inferred from Mutant Phenotype
more info
PubMed 
endosome organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein localization to organelle IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
multivesicular body IDA
Inferred from Direct Assay
more info
PubMed 
organelle IDA
Inferred from Direct Assay
more info
PubMed 
recycling endosome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
Apoptosis-linked gene 2-interacting protein X 1
NP_001022713.1
  • Confirmed by transcript evidence
NP_001022714.1
  • Confirmed by transcript evidence
NP_001022715.1
  • Confirmed by transcript evidence
NP_499213.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    9957351..9963132
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001027543.3NP_001022714.1  Apoptosis-linked gene 2-interacting protein X 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022714.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34552
    Conserved Domains (3) summary
    cd09235
    Location:366704
    V_Alix; Middle V-domain of mammalian Alix and related domains are dimerization and protein interaction modules
    cd09240
    Location:4351
    BRO1_Alix; Protein-interacting, N-terminal, Bro1-like domain of mammalian Alix and related domains
    pfam13949
    Location:419707
    ALIX_LYPXL_bnd; ALIX V-shaped domain binding to HIV
  2. NM_001027542.3NP_001022713.1  Apoptosis-linked gene 2-interacting protein X 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022713.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34552
    Conserved Domains (3) summary
    cd09235
    Location:366704
    V_Alix; Middle V-domain of mammalian Alix and related domains are dimerization and protein interaction modules
    cd09240
    Location:4351
    BRO1_Alix; Protein-interacting, N-terminal, Bro1-like domain of mammalian Alix and related domains
    pfam13949
    Location:419707
    ALIX_LYPXL_bnd; ALIX V-shaped domain binding to HIV
  3. NM_066812.6NP_499213.1  Apoptosis-linked gene 2-interacting protein X 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499213.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34552
    Conserved Domains (3) summary
    cd09235
    Location:366704
    V_Alix; Middle V-domain of mammalian Alix and related domains are dimerization and protein interaction modules
    cd09240
    Location:4351
    BRO1_Alix; Protein-interacting, N-terminal, Bro1-like domain of mammalian Alix and related domains
    pfam13949
    Location:419707
    ALIX_LYPXL_bnd; ALIX V-shaped domain binding to HIV
  4. NM_001027544.2NP_001022715.1  Apoptosis-linked gene 2-interacting protein X 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022715.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34552
    Conserved Domains (1) summary
    cd09240
    Location:4351
    BRO1_Alix; Protein-interacting, N-terminal, Bro1-like domain of mammalian Alix and related domains
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