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sas-4 Spindle assembly abnormal protein 4 [ Caenorhabditis elegans ]

Gene ID: 176172, updated on 11-Apr-2024

Summary

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Gene symbol
sas-4
Gene description
Spindle assembly abnormal protein 4
Primary source
WormBase:WBGene00004726
Locus tag
CELE_F10E9.8
See related
AllianceGenome:WB:WBGene00004726
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in centriole replication and maintenance of protein location. Located in centriole. Is expressed in gonad; intestinal cell; and sperm. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: III
Exon count:
10
Sequence:
Chromosome: III; NC_003281.10 (8314349..8318588, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene rRNA-processing protein FYV7 Neighboring gene Transmembrane protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Centrosome size is controlled by centriolar SAS-4. Salisbury JL. Trends Cell Biol, 2003 Jul. PMID 12837604
  2. Dispatch. Centrosome biology: a SAS-sy centriole in the cell cycle. Wong C, et al. Curr Biol, 2003 Apr 29. PMID 12725749
  3. SAS-4 is essential for centrosome duplication in C elegans and is recruited to daughter centrioles once per cell cycle. Leidel S, et al. Dev Cell, 2003 Mar. PMID 12636923
  4. SAS-4 is a C. elegans centriolar protein that controls centrosome size. Kirkham M, et al. Cell, 2003 Feb 21. PMID 12600319
  5. Interaction between the Caenorhabditis elegans centriolar protein SAS-5 and microtubules facilitates organelle assembly. Bianchi S, et al. Mol Biol Cell, 2018 Mar 15. PMID 29367435, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Centriolar SAS-4 remains in dynamic equilibrium with the cytoplasmic pool until late prophase, when it is stably incorporated in a step that requires gamma-tubulin and microtubule assembly.
    Title: SAS-4 is recruited to a dynamic structure in newly forming centrioles that is stabilized by the gamma-tubulin-mediated addition of centriolar microtubules.
  2. SAS-4 is recruited to the centrosome once per cell cycle, at the time of organelle duplication; then to the daughter centriole or a closely associated structure. SAS-4 recruitment is a key step in the centrosome duplication cycle.
    Title: SAS-4 is essential for centrosome duplication in C elegans and is recruited to daughter centrioles once per cell cycle.
  3. SAS-4 is a centriole-associated component whose amount dictates centrosome size
    Title: SAS-4 is a C. elegans centriolar protein that controls centrosome size.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in centriole replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in maintenance of protein location IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in centriole IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Spindle assembly abnormal protein 4
NP_498828.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    8314349..8318588 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066427.8 → NP_498828.2  Spindle assembly abnormal protein 4 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498828.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34402
    Conserved Domains (2) summary
    pfam10211
    Location:394 → 481
    Ax_dynein_light; Axonemal dynein light chain
    cl19849
    Location:439 → 541
    DUF881; Bacterial protein of unknown function (DUF881)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P34402.2

Gene LinkOut

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