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aco-2 Probable aconitate hydratase, mitochondrial [ Caenorhabditis elegans ]

Gene ID: 176121, updated on 22-Feb-2019

Summary

Gene symbol
aco-2
Gene description
Probable aconitate hydratase, mitochondrial
Primary source
WormBase:WBGene00000041
Locus tag
CELE_F54H12.1
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis

Genomic context

See aco-2 in Genome Data Viewer
Location:
chromosome: III
Exon count:
6
Sequence:
Chromosome: III; NC_003281.10 (7973725..7976958)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Probable elongation factor 1-beta/1-delta 1 Neighboring gene ncRNA Neighboring gene hypothetical protein Neighboring gene tRNA Neighboring gene ncRNA

Pathways from BioSystems

General gene information

Markers

Homology

  • Homologs of the aco-2 gene: The aco-2 gene is conserved in human, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, and frog.
  • Orthologs

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
4 iron, 4 sulfur cluster binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
aconitate hydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
aconitate hydratase activity IEA
Inferred from Electronic Annotation
more info
 
iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
lyase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
tricarboxylic acid cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion HDA PubMed 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Probable aconitate hydratase, mitochondrial
NP_498738.2
  • Confirmed by transcript evidence
NP_741235.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    7973725..7976958
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_171200.4NP_741235.1  Probable aconitate hydratase, mitochondrial [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741235.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34455
    Conserved Domains (3) summary
    cd01584
    Location:92502
    AcnA_Mitochondrial; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle
    cd01578
    Location:581729
    AcnA_Mitochon_Swivel; Mitochondrial aconitase A swivel domain. Aconitase (also known as aconitate hydratase and citrate hydro-lyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes ...
    TIGR01340
    Location:42769
    aconitase_mito; aconitate hydratase, mitochondrial
  2. NM_066337.5NP_498738.2  Probable aconitate hydratase, mitochondrial [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498738.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34455
    Conserved Domains (3) summary
    cd01584
    Location:1408
    AcnA_Mitochondrial; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle
    cd01578
    Location:487635
    AcnA_Mitochon_Swivel; Mitochondrial aconitase A swivel domain. Aconitase (also known as aconitate hydratase and citrate hydro-lyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes ...
    TIGR01340
    Location:1675
    aconitase_mito; aconitate hydratase, mitochondrial
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