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gly-3 Polypeptide N-acetylgalactosaminyltransferase 3 [ Caenorhabditis elegans ]

Gene ID: 176112, updated on 23-Apr-2026
Official Symbol
gly-3
Official Full Name
Polypeptide N-acetylgalactosaminyltransferase 3
Primary source
WormBase:WBGene00001628
Locus tag
CELE_ZK688.8
See related
AllianceGenome:WB:WBGene00001628
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables polypeptide N-acetylgalactosaminyltransferase activity. Involved in protein O-linked glycosylation via threonine. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus. Is expressed in hypodermis; intestine; rectal gland cell; and reproductive system. Orthologous to several human genes including GALNT1 (polypeptide N-acetylgalactosaminyltransferase 1). [provided by Alliance of Genome Resources, Jul 2025]
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See gly-3 in Genome Data Viewer
Location:
chromosome: III
Exon count:
6
Sequence:
Chromosome: III; NC_003281.10 (7914311..7917767, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Putative protein tag-250 Neighboring gene ncRNA Neighboring gene EF-hand domain-containing protein

Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. cDNA cloning and expression of a family of UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase sequence homologs from Caenorhabditis elegans. Hagen FK, et al. J Biol Chem, 1998 Apr 3. PMID 9525933
  2. The terminal phase of cytokinesis in the Caenorhabditis elegans early embryo requires protein glycosylation. Wang H, et al. Mol Biol Cell, 2005 Sep. PMID 15987734, Free PMC Article
  3. Functional conservation of subfamilies of putative UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferases in Drosophila, Caenorhabditis elegans, and mammals. One subfamily composed of l(2)35Aa is essential in Drosophila. Schwientek T, et al. J Biol Chem, 2002 Jun 21. PMID 11925450
  4. Carbohydrates and glycosylation. Berninsone PM. WormBook, 2006 Dec 18. PMID 18050430, Free PMC Article
  5. MACSPI enables tissue-selective proteomic and interactomic analyses in multicellular organisms. Huang S, et al. Proc Natl Acad Sci U S A, 2024 May 21. PMID 38753516, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables polypeptide N-acetylgalactosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables polypeptide N-acetylgalactosaminyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables polypeptide N-acetylgalactosaminyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein O-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
Polypeptide N-acetylgalactosaminyltransferase 3
NP_498722.1
  • Confirmed by transcript evidence

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    7914311..7917767 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066321.8 → NP_498722.1  Polypeptide N-acetylgalactosaminyltransferase 3

    See identical proteins and their annotated locations for NP_498722.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34678, Q9U003
    Conserved Domains (4) summary
    cd02510
    Location:173 → 473
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    cd00161
    Location:486 → 604
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
    pfam00652
    Location:486 → 604
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
    pfam10111
    Location:173 → 438
    Glyco_tranf_2_2; Glycosyltransferase like family 2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P34678.2

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