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coq-5 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial [ Caenorhabditis elegans ]

Gene ID: 176099, updated on 11-Apr-2024

Summary

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Gene symbol
coq-5
Gene description
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial
Primary source
WormBase:WBGene00000765
Locus tag
CELE_ZK652.9
See related
AllianceGenome:WB:WBGene00000765
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable methyltransferase activity. Involved in ubiquinone biosynthetic process. Predicted to be located in mitochondrial inner membrane. Predicted to be extrinsic component of mitochondrial inner membrane. Human ortholog(s) of this gene implicated in primary coenzyme Q10 deficiency 9. Orthologous to human COQ5 (coenzyme Q5, methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: III
Exon count:
3
Sequence:
Chromosome: III; NC_003281.10 (7857315..7858457, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Large ribosomal subunit protein uL29 Neighboring gene ApaG domain-containing protein Neighboring gene Ubiquitin-fold modifier 1 Neighboring gene ncRNA Neighboring gene Mitochondrial import receptor subunit TOM7 homolog

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Caenorhabditis elegans ubiquinone biosynthesis genes. Rodríguez-Aguilera JC, et al. Biofactors, 2003. PMID 14695939
  2. Silencing of ubiquinone biosynthesis genes extends life span in Caenorhabditis elegans. Asencio C, et al. FASEB J, 2003 Jun. PMID 12709403
  3. C. elegans ORFeome version 1.1: experimental verification of the genome annotation and resource for proteome-scale protein expression. Reboul J, et al. Nat Genet, 2003 May. PMID 12679813
  4. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
  5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in quinone biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquinone biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquinone biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquinone biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in extrinsic component of mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial
NP_498704.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    7857315..7858457 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066303.9 → NP_498704.1  2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498704.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34666
    Conserved Domains (1) summary
    TIGR01934
    Location:57 → 282
    MenG_MenH_UbiE; ubiquinone/menaquinone biosynthesis methyltransferases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P34666.2

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