cgh-1 ATP-dependent RNA helicase cgh-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: cgh-1
Official Full Name: ATP-dependent RNA helicase cgh-1
Primary source: WormBase:WBGene00000479
Locus tag: CELE_C07H6.5
See related: AllianceGenome:WB:WBGene00000479
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable RNA helicase activity and mRNA binding activity. Involved in several processes, including P-body assembly; determination of adult lifespan; and negative regulation of translation. Located in P granule; P-body; and cytoplasmic stress granule. Part of ribonucleoprotein complex. Is expressed in several structures, including Z2; Z3; germ line; gonad; and neurons. Orthologous to human DDX6 (DEAD-box helicase 6). [provided by Alliance of Genome Resources, Jul 2025]
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Genomic context

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See cgh-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 4

Sequence:: Chromosome: III; NC_003281.10 (7495320..7497832, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Insight into the interaction between the RNA helicase CGH-1 and EDC-3 and its implications.
Title: Insight into the interaction between the RNA helicase CGH-1 and EDC-3 and its implications.
CPB-3 and CGH-1 localize to motile particles within dendrites in C. elegans PVD sensory neurons.
Title: CPB-3 and CGH-1 localize to motile particles within dendrites in C. elegans PVD sensory neurons.
Structural and biochemical insights into the recognition of RNA helicase CGH-1 by CAR-1 in C. elegans.
Title: Structural and biochemical insights into the recognition of RNA helicase CGH-1 by CAR-1 in C. elegans.
The mRNA Decay Factor CAR-1/LSM14 Regulates Axon Regeneration via Mitochondrial Calcium Dynamics.
Title: The mRNA Decay Factor CAR-1/LSM14 Regulates Axon Regeneration via Mitochondrial Calcium Dynamics.
CGH-1 regulates remodeling of the endoplasmic reticulum in C. elegans oocytes.
Title: Remodeling of the endoplasmic reticulum in Caenorhabditis elegans oocytes is regulated by CGH-1.
Data show that DEAD-box RNA helicase, CGH-1/DDX6, as a key casein kinase II (CK2) substrate and phosphorylation of a conserved N-terminal serine is required for CGH-1 function in the microRNA (miRNA) pathway.
Title: Casein kinase II promotes target silencing by miRISC through direct phosphorylation of the DEAD-box RNA helicase CGH-1.
These results identify somatic and germ cell CGH-1 functions that are distinguished by the involvement of PATR-1, and reveal that during oogenesis, numerous translationally regulated mRNAs are specifically protected by a CGH-1-dependent mechanism.
Title: Protection of specific maternal messenger RNAs by the P body protein CGH-1 (Dhh1/RCK) during Caenorhabditis elegans oogenesis.
in developing oocytes CGH-1 particles accumulate specifically in response to meiotic development
Title: Requirement for P granules and meiosis for accumulation of the germline RNA helicase CGH-1.
Regulation of physiological germ cell apoptosis is specifically influenced by certain functions of the CGH-1/CAR-1 RNA-proteinP complex.
Title: A conserved RNA-protein complex component involved in physiological germline apoptosis regulation in C. elegans.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C07H6.5 (e-PCR)
- UniSTS:308993

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables RNA helicase activity	IEA Inferred from Electronic Annotation more info
enables RNA helicase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in P-body assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in P-body assembly	IEA Inferred from Electronic Annotation more info
involved_in P-body assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gamete generation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA metabolic process	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of translation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in stress granule assembly	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in P granule	IDA Inferred from Direct Assay more info	PubMed
located_in P granule	IEA Inferred from Electronic Annotation more info
is_active_in P-body	IBA Inferred from Biological aspect of Ancestor more info
located_in P-body	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	EXP Inferred from Experiment more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasmic stress granule	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic stress granule	IDA Inferred from Direct Assay more info	PubMed
part_of ribonucleoprotein complex	IDA Inferred from Direct Assay more info	PubMed
part_of ribonucleoprotein granule	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ATP-dependent RNA helicase cgh-1

NP_498646.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

7495320..7497832 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_066245.8 → NP_498646.1 ATP-dependent RNA helicase cgh-1

See identical proteins and their annotated locations for NP_498646.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q95YF3

Conserved Domains (3) summary

PTZ00424
Location:1 → 418

PTZ00424; helicase 45; Provisional

cd00079
Location:255 → 383

HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...

cd00268
Location:45 → 245

DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...