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acs-4 long-chain-fatty-acid--CoA ligase [ Caenorhabditis elegans ]

Gene ID: 176005, updated on 22-May-2024

Summary

Gene symbol
acs-4
Gene description
long-chain-fatty-acid--CoA ligase
Primary source
WormBase:WBGene00018152
Locus tag
CELE_F37C12.7
See related
AllianceGenome:WB:WBGene00018152
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable long-chain fatty acid-CoA ligase activity. Predicted to be involved in long-chain fatty acid metabolic process; long-chain fatty-acyl-CoA metabolic process; and neuron differentiation. Located in lipid droplet. Is expressed in hypodermis; intestine; neurons; pharynx; and somatic nervous system. Human ortholog(s) of this gene implicated in asthma; breast cancer; intellectual disability; non-syndromic X-linked intellectual disability 63; and prostate cancer. Orthologous to human ACSL3 (acyl-CoA synthetase long chain family member 3) and ACSL4 (acyl-CoA synthetase long chain family member 4). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See acs-4 in Genome Data Viewer
Location:
chromosome: III
Exon count:
6
Sequence:
Chromosome: III; NC_003281.10 (7167838..7170990)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Pre-mRNA-splicing factor syf-2 Neighboring gene Integrase zinc-binding domain-containing protein Neighboring gene pseudo Neighboring gene pseudo

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables long-chain fatty acid-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in long-chain fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in long-chain fatty-acyl-CoA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in lipid droplet IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in lipid droplet IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
long-chain-fatty-acid--CoA ligase
NP_498568.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    7167838..7170990
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066167.9NP_498568.1  long-chain-fatty-acid--CoA ligase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498568.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q20121
    Conserved Domains (2) summary
    cd05927
    Location:137725
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    PLN02387
    Location:91725
    PLN02387; long-chain-fatty-acid-CoA ligase family protein