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atgl-1 PNPLA domain-containing protein;Patanin-like phospholipase domain-containing protein atgl-1 [ Caenorhabditis elegans ]

Gene ID: 175910, updated on 12-Jun-2024

Summary

Gene symbol
atgl-1
Gene description
PNPLA domain-containing protein;Patanin-like phospholipase domain-containing protein atgl-1
Locus tag
CELE_C05D11.7
See related
AllianceGenome:WB:WBGene00015484
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable triglyceride lipase activity. Predicted to be involved in lipid homeostasis and triglyceride catabolic process. Located in lipid droplet. Is expressed in several structures, including body wall musculature; intestine; nervous system; non-striated muscle; and pharynx. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 10; coronary artery disease; fatty liver disease (multiple); liver disease (multiple); and type 2 diabetes mellitus. Orthologous to several human genes including PNPLA2 (patatin like phospholipase domain containing 2) and PNPLA3 (patatin like phospholipase domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See atgl-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
8
Sequence:
Chromosome: III; NC_003281.10 (6415772..6419459, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Protein let-756 Neighboring gene Putative hydroxypyruvate isomerase Neighboring gene Metalloendopeptidase;Zinc metalloproteinase nas-4 Neighboring gene FHIP family protein C05D11.8 Neighboring gene Ribonucleases P/MRP protein subunit popl-1

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables triglyceride lipase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables triglyceride lipase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in triglyceride catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in triglyceride catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in lipid droplet IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in lipid droplet IDA
Inferred from Direct Assay
more info
PubMed 
located_in lipid droplet IEA
Inferred from Electronic Annotation
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
PNPLA domain-containing protein;Patanin-like phospholipase domain-containing protein atgl-1
NP_741195.1
  • Confirmed by transcript evidence
NP_741196.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    6415772..6419459 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_171168.6NP_741196.1  Patanin-like phospholipase domain-containing protein atgl-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741196.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q11186
    Conserved Domains (1) summary
    cd07204
    Location:12252
    Pat_PNPLA_like; Patatin-like phospholipase domain containing protein family
  2. NM_171167.6NP_741195.1  PNPLA domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741195.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T3F2
    Conserved Domains (1) summary
    cd07204
    Location:12252
    Pat_PNPLA_like; Patatin-like phospholipase domain containing protein family