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let-756 Protein let-756 [ Caenorhabditis elegans ]

Gene ID: 175909, updated on 9-Dec-2024

Summary

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Official Symbol
let-756
Official Full Name
Protein let-756
Primary source
WormBase:WBGene00002881
Locus tag
CELE_C05D11.4
See related
AllianceGenome:WB:WBGene00002881
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables RNA polymerase II-specific DNA-binding transcription factor binding activity; growth factor activity; and protein kinase binding activity. Involved in several processes, including fibroblast growth factor receptor signaling pathway; nematode larval development; and regulation of axon extension involved in axon guidance. Located in cytoplasm; extracellular space; and nuclear lumen. Is expressed in several structures, including body wall musculature; cephalic sensillum; muscle cell; neurons; and pharynx. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); bone disease (multiple); brain disease (multiple); cognitive disorder (multiple); and urinary system cancer (multiple). Orthologous to several human genes including FGF3 (fibroblast growth factor 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See let-756 in Genome Data Viewer
Location:
chromosome: III
Exon count:
8
Sequence:
Chromosome: III; NC_003281.10 (6407129..6410033)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Putative hydroxypyruvate isomerase Neighboring gene Metalloendopeptidase;Zinc metalloproteinase nas-4 Neighboring gene PNPLA domain-containing protein;Patatin-like phospholipase domain-containing protein atgl-1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Intracellular trafficking of LET-756, a fibroblast growth factor of C. elegans, is controlled by a balance of export and nuclear signals. Popovici C, et al. Exp Cell Res, 2006 May 15. PMID 16487967
  2. FGF signaling in flies and worms: more and more relevant to vertebrate biology. Huang P, et al. Cytokine Growth Factor Rev, 2005 Apr. PMID 15863031
  3. Serine hydroxymethyltransferase is maternally essential in Caenorhabditis elegans. Vatcher GP, et al. J Biol Chem, 1998 Mar 13. PMID 9497323
  4. Alternative splicing affecting a novel domain in the C. elegans EGL-15 FGF receptor confers functional specificity. Goodman SJ, et al. Development, 2003 Aug. PMID 12835392
  5. let-756, a C. elegans fgf essential for worm development. Roubin R, et al. Oncogene, 1999 Nov 18. PMID 10597282

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the EFISIA motif in the core of LET-756 is essential for its biological activity
    Title: Functional phylogeny relates LET-756 to fibroblast growth factor 9.
  2. LET-756, like vertebrate FGF9, -16, and -20, belongs to the FGF9 family, whereas EGL-17, like vertebrate FGF8, -17, and -18, could be included in the FGF8 family [review]
    Title: A pair as a minimum: the two fibroblast growth factors of the nematode Caenorhabditis elegans.
  3. LET-756 exerts its functions through a balance between a synergy of several nuclear localization signals and attenuated secretion signal.
    Title: Intracellular trafficking of LET-756, a fibroblast growth factor of C. elegans, is controlled by a balance of export and nuclear signals.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables fibroblast growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fibroblast growth factor receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables growth factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
  
enables growth factor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in fibroblast growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fibroblast growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cell projection organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nematode larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neurogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of axon extension involved in axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Protein let-756
NP_498403.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    6407129..6410033
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066002.7 → NP_498403.1  Protein let-756 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498403.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O76831, Q11184
    Conserved Domains (1) summary
    smart00442
    Location:70 → 209
    FGF; Acidic and basic fibroblast growth factor family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q11184.2

Gene LinkOut

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